应用数值模拟技术在脑梗死的研究进展  

Research progress of the application of numerical simulation technology in cerebral infarction

作　　者：陈晓琴 成志国 陈广新[1] 明照凯 钟彦 沈文哲 周志尊[1] CHEN Xiaoqin;CHENG Zhiguo;CHEN Guangxin;MING Zhaokai;ZHONG Yan;SHEN Wenzhe;ZHOU Zhizun(School of Medical Imaging,Mudanjiang Medical University,Heilongjiang,Mudanjiang 157011,China)

机构地区：[1]牡丹江医学院医学影像学院,黑龙江牡丹江157011

出　　处：《中国医药科学》2022年第5期57-60,共4页China Medicine And Pharmacy

摘　　要：脑梗死是大脑供血动脉的狭窄或闭塞,引起脑组织血液供应障碍从而导致脑组织坏死及软化。近年来,使用数值模拟技术分析脑梗死已逐渐成熟,可进行定量定性的计算。本研究查阅相关数值模拟研究内容,介绍相关参数指标,分析数值模拟技术应用于血管分叉病变及脑梗死研究,得出高低值壁面切应力的不同作用机制及高壁面压力导致斑块形成的可能机制,同时明确极低或较高壁面剪应力及高振荡剪切指数更易造成动脉粥样硬化斑块的形成,以及动脉血管改变(如狭窄或闭塞等)易发生不稳定的血流动力学变化,使脑梗死发生概率增大,明确了数值模拟技术在脑梗死发生中的重要作用。Cerebral infarction is the stenosis or occlusion of cerebral blood supply arteries,which leads to the blood supply disorder in brain tissues,thus resulting in brain tissue necrosis and softening.In recent years,the application of numerical simulation technology to analyze cerebral infarction has gradually grown mature,which can be used for quantitative and qualitative calculation.This paper refers to relevant numerical simulation researches,introduces relevant parameters and indexes,analyzes the application of numerical simulation technology in the studies of vascular bifurcation lesions and cerebral infarction,and obtains different action mechanisms of high and low wall shear stress and the possible mechanism underlying plaque formation caused by high wall pressure.At the same time,the paper clarifies that very low or relatively high wall shear stress and high oscillatory shear index are more likely to incur the formation of atherosclerotic plaque,and that arterial changes(such as stenosis or occlusion)are prone to result in unstable hemodynamic changes,which increases the probability of cerebral infarction.This paper also specifies the important role of numerical simulation technology in the occurrence of cerebral infarction.

关 键 词：脑梗死 数值模拟技术 动脉粥样硬化 壁面切应力 壁面压力 

分 类 号：R739.4[医药卫生—肿瘤] R273[医药卫生—临床医学]