Regulative role of the CXCL13-CXCR5 axis in the tumor microenvironment  

作　　者：Ping Tan Ming Shi Li Lai Zhuang Tang Nan Xie Hang Xu Qiang Wei Xiaoyu Zhang Lu Yang Lily Wu 

机构地区：[1]Department of Urology,Institute of Urology,West China Hospital,Sichuan University,Chengdu,Sichuan [2]The Center of Anesthesiology and Surgery,West China Hospital,sichuan University,Chengdu,Sichuan [3]Department of Emergency,West China Hospital,Sichuan University,Chengdu,Sichuan [4]Department of Molecular and Medical Phamacology,David Geffen School of Medicine,University of California,Los Angeles,CA 90095,USA [5]Department of Urology,David Geffen School of Medicine,University of California,Los Angeles,CA 90095,USA

出　　处：《Precision Clinical Medicine》2018年第1期49-56,共8页精准临床医学（英文）

基　　金：supported by the National Key Research and Development Program of China(Grant No.SQ2017YFSF090096);the Prostate Cancer Foundation Young Investigator Award 2013;the National Natural Science Foundation of China(Grant No.81300627,81370855,81702536,81770756);Programs from Science and Technology Department of Sichuan Province(Grant No.2018JY0089 and 2017HH0063);Young Investigator Award of Sichuan University 2017.

摘　　要：Chemokines are best known for their abilities of recruiting immune cells and forming lymphoid tissue.Through interactions between chemokines and their receptors,various immune cell subsets are recruited into the tumor microenvironment which is the primary location for tumor cells interacting with responding host cells.In recent decades,a large volume of studies have revealed chemokines'role in the tumor microenviron-ment in regulating tumor growth,invasion,and/or metastasis as well as tumor immune response;however,their molecular mechanisms are not well understood.Recently,increasing evidence has reported the import-ance of the CXCL13-CXCR5 axis in the tumor microenvironment of vanious human malignancies.Thus,in this review,we will focus on the CXCL13-CXCR5 axis and elaborate on the expression patterns,regulating and cor-responding regulatory mechanisms as well as clinical values in a wide range of human cancers.

关 键 词：CHEMOKINE CXCL13 CXCR5 tumor microenvironment 

分 类 号：R73[医药卫生—肿瘤]