EnhFFL:A database of enhancer mediated feed-forward loops for human and mouse  

作　　者：Ran Kang Zhengtang Tan Mei Lang Linqi Jin Yin Zhang Yiming Zhang Tailin Guo Zhiyun Guo 

机构地区：[1]School of Life Sciences and Engineering,Southwest Jiaotong University,Chengdu 610031,China [2]College of Medicine,Southwest Jiaotong University,Chengdu 610031,China

出　　处：《Precision Clinical Medicine》2021年第2期129-135,共7页精准临床医学（英文）

基　　金：The research was supported by the Basic Research Cultivation Support Programof Fundamental Research Funds for the Central Universities,the National Natural Science Foundation of China(Grant No.32071343);the Sichuan Science and Technology Program(Grant No.2021YJ0048).

摘　　要：Feed-forward loops(FFLs)are thought to be one of the most common and important classes of transcriptional network motifs involved in various diseases.Enhancers are cis-regulatory elements that positively regulate protein-coding genes or microRNAs(miRNAs)by recruiting DNA-binding transcription factors(TFs).However,a comprehensive resource to identify,store,and analyze the FFLs of typical enhancer and super-enhancer FFLs is not currently available.Here,we present EnhFFL,an online database to provide a data resource for users to browse and search typical enhancer and super-enhancer FFLs.The current database covers 46280/7000 TFenhancer-miRNA FFLs,9997/236 enhancer-miRNA-gene FFLs,3561164/3193182 TF-enhancer-gene FFLs,and 1259/235 TF-enhancer feed-back loops(FBLs)across 91 tissues/cell lines of human and mouse,respectively.Users can browse loops by selecting species,types of tissue/cell line,and types of FFLs.EnhFFL supports searching elements including name/ID,genomic location,and the conservation of miRNA target genes.We also developed tools for users to screen customized FFLs using the threshold of q value as well as the confidence score of miRNA target genes.Disease and functional enrichment analysis showed that master miRNAs that are widely engaged in FFLs including TF-enhancer-miRNAs and enhancer-miRNA-genes are significantly involved in tumorigenesis.Database URL:http://lcbb.swjtu.edu.cn/EnhFFL/.

关 键 词：DATABASE ENHANCER miRNA transcription factor feed-forward loop 

分 类 号：R73[医药卫生—肿瘤]