Intestinal Wnt in the transition from physiology to oncology  

作　　者：Julia Swoboda Patrick Mittelsdorf Yuan Chen Ralf Weiskirchen Johannes Stallhofer Silke Schüle Nikolaus Gassler 

机构地区：[1]Section Pathology,Institute of Forensic Medicine,Jena University Hospital,Jena 07747,Germany [2]Institute of Molecular Pathobiochemistry,Experimental Gene Therapy and Clinical Chemistry,RWTH University Hospital Aachen,Aachen 52074,Germany [3]Department of Internal Medicine IV(Gastroenterology,Hepatology,and Infectious Diseases),Jena University Hospital,Jena 07747,Germany [4]Department of General,Visceral and Vascular Surgery,Jena University Hospital,Jena 07747,Germany

出　　处：《World Journal of Clinical Oncology》2022年第3期168-185,共18页世界临床肿瘤学杂志（英文版）

摘　　要：Adult stem cells are necessary for self-renewal tissues and regeneration after damage.Especially in the intestine,which self-renews every few days,they play a key role in tissue homeostasis.Therefore,complex regulatory mechanisms are needed to prevent hyperproliferation,which can lead in the worst case to carcinogenesis or under-activation of stem cells,which can result in dysfunctional epithelial.One main regulatory signaling pathway is the Wnt/β-catenin signaling pathway.It is a highly conserved pathway,withβ-catenin,a transcription factor,as target protein.Translocation ofβ-catenin from cytoplasm to nucleus activates the transcription of numerous genes involved in regulating stem cell pluripotency,proliferation,cell differentiation and regulation of cell death.This review presents a brief overview of the Wnt/β-catenin signaling pathway,the regulatory mechanism of this pathway and its role in intestinal homeostasis.Additionally,this review highlights the molecular mechanisms and the histomorphological features of Wnt hyperactivation.Furthermore,the central role of the Wnt signaling pathway in intestinal carcinogenesis as well as its clinical relevance in colorectal carcinoma are discussed.

关 键 词：Wnt signaling BETA-CATENIN INTESTINE Colorectal cancer Cell signaling Intestinal stem cells 

分 类 号：R735.34[医药卫生—肿瘤]