BETA-CATENIN

作品数：62被引量：294H指数：9
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相关领域：医药卫生更多>>
相关作者：陈国茜林晓李昱童津津邝高艳更多>>
相关机构：重庆医科大学南昌大学山东师范大学湖南中医药大学更多>>
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相关基金：国家自然科学基金湖南省自然科学基金北京市自然科学基金重庆医科大学科研启动基金更多>>
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Polyphyllin Ⅰ enhances tumor necrosis factor-related apoptosis-inducing ligand-induced inhibition of human osteosarcoma cell growth via downregulating the Wnt/β-catenin pathway被引量：1
《Journal of Traditional Chinese Medicine》2024年第2期251-259,共9页CHANG Junli ZHAO Fulai SUN Xingyuan MA Xiaoping ZHAO Peng ZHOU Chujie SHI Binhao GU Wenchao WANG Yongjun YANG Yanping 
National Key R&D Program of China:Cooperating Studies on Measurement Technologies of Human Phenome and Crossscale Correlation of Phenotypic Data(No.2020YFE0201600);National Nature Science Foundation:Study on LncRNA-CCDC18-AS1 Mediated Osteosarcoma Occurrence by Activating YAP/TAZ and Tumor Microenvironment M2 TAM-dependent Lung Metastasis,and Efficacy/mechanism of Removing Blood Stasis/clearing heat/eliminating Toxic Material Principle(No.81973877);Mechanism Study on m6A Methyltransferase RBM15 Mediated YAP Epigenetic Modification to Promote Osteosarcoma Lung Metastasis through Lymphatic System and Management with Qichong Powder(No.82174408);Shanghai Collaborative Innovation Center of Industrial Transformation of Hospital TCM Preparation:Preclinical Study on the Treatment of Osteosarcoma with Qingre Jiedu Granules;Research Projects within Budget of Shanghai University of Traditional Chinese Medicine:the Research on the Mechanism of the HIPK3 Activation of Wnt/β-catenin Induction the Osteosarcoma and the Intervention of Banmao Decoction(No.2021LK047)。
OBJECTIVE:To investigate the synergistic effects of polyphyllin Ⅰ(PPⅠ)combined with tumor necrosis factorrelated apoptosis-inducing ligand(TRAIL)on the growth of osteosarcoma cells through downregulating the Wnt/β-...
关键词：OSTEOSARCOMA tumor necrosis factor-related apoptosis-inducing ligand Wnt signaling pathway BETA-CATENIN polyphyllinⅠ 
Wnt/beta-catenin signaling inhibitors and nonalcoholic fatty liver disease:Potential therapeutic implications
《Hepatobiliary & Pancreatic Diseases International》2023年第4期437-438,共2页Stergios A Polyzos Jannis Kountouras Athanasios D Anastasilakis Evangelos Terpos 
To the Editor:We read with considerable interest the paper of Shree Harini and Ezhilarasan,summarizing the possible pathophysiological connections between the modulators of canonical Wnt/β-catenin pathway and nonalco...
关键词：HEPATIC NAFLD NONALCOHOLIC 
Reply to“Wnt/beta-catenin signaling inhibitors and nonalcoholic fatty liver disease:Potential therapeutic implications”
《Hepatobiliary & Pancreatic Diseases International》2023年第4期439-440,共2页Karthik Shree Harini Devaraj Ezhilarasan 
supported by a grant from the Extramural Re-search Project-Indian Council of Medical Research,New Delhi,In-dia(58/30/2020/PHA/BMS dtd.9.11.2021).
The Author Reply:We sincerely appreciated the interest of Polyzos et al.,in our review article and sharing their improvised thoughts regarding the Wnt signaling modulators for the treatment of postmenopausal women wit...
关键词：liver WNT constantly 
Role of Iron Accumulation in Osteoporosis and the Underlying Mechanisms被引量：4
《Current Medical Science》2023年第4期647-654,共8页Guang-fei LI Yan GAO E.D.WEINBERG Xi HUANG You-jia XU 
supported by grants from the National Natural Science Foundation of China(No.81500680,No.81874018);the Youth Elite Program of Jiangsu Province(No.QNRC2016878).
Osteoporosis is prevalent in postmenopausal women.The underlying reason is mainly estrogen deficiency,but recent studies have indicated that osteoporosis is also associated with iron accumulation after menopause.It ha...
关键词：MENOPAUSE OSTEOBLASTS OSTEOCLASTS Wnt/Beta-catenin HEDGEHOG 
Wnt/beta-catenin signaling and its modulators in nonalcoholic fatty liver diseases被引量：4
《Hepatobiliary & Pancreatic Diseases International》2023年第4期333-345,共13页Karthik Shree Harini Devaraj Ezhilarasan 
supported by a grant from the Extramural Re-search Project,Indian Council of Medical Research,New Delhi,In-dia(58/30/2020/PHA/BMS dtd 9.11.2021).
Nonalcoholic fatty liver disease(NAFLD)is a global health concern associated with significant morbidity and mortality.NAFLD is a spectrum of diseases originating from simple steatosis,progressing through nonalcoholic ...
关键词：STEATOSIS Fatty liver Oxidative stress Chronic liver diseases FIBROSIS WNT/Β-CATENIN 
The Role and Mechanism of LncRNA-p21 in Regulating Gastric Cancer Metastasis by Mediating Wnt/β-Catenin Signaling Pathway被引量：1
《Journal of Clinical and Nursing Research》2023年第3期143-148,共6页Peng Liu Haizhe Chang Xinyu Peng Xiu Zhang Jianjun Zhang Jiusong Luan 
Objective:To study the mechanism of lncRNA p21 inhibiting the growth and metastasis of human gastric cancer SGC7901/GES-1 cells by mediating the Wnt/β-catenin signaling pathway.Methods:Lentiviral overexpression of ln...
关键词：LncRNA-p21 Wnt/beta-catenin signaling pathway Gastric cancer 
CDK5 inhibition promotes osteoblastic differentiation of MSCs and blocks the migration of osteosarcoma MG-63 cells
《BIOCELL》2022年第4期1067-1078,共12页HONG FU HAOYU ZHAO YALI YANG SIYU WANG KE DUAN TAILIN GUO 
supported by the National Natural Science Foundation of China under Grant(32071343);Fundamental Research Funds for the Central Universities under Grant(2682020ZT80);Sichuan Science and Technology Program under Grant(21YYJC3323).
CDK5 belongs to the cyclin-dependent kinase family.CDK5 is multifunctional and plays an important role in neural differentiation.However,the role of CDK5 in osteoblastic differentiation remains unclear.The present stu...
关键词：F-ACTIN YAP BETA-CATENIN Nuclear localization MSC differentiation 
Intestinal Wnt in the transition from physiology to oncology被引量：2
《World Journal of Clinical Oncology》2022年第3期168-185,共18页Julia Swoboda Patrick Mittelsdorf Yuan Chen Ralf Weiskirchen Johannes Stallhofer Silke Schüle Nikolaus Gassler 
Adult stem cells are necessary for self-renewal tissues and regeneration after damage.Especially in the intestine,which self-renews every few days,they play a key role in tissue homeostasis.Therefore,complex regulator...
关键词：Wnt signaling BETA-CATENIN INTESTINE Colorectal cancer Cell signaling Intestinal stem cells 
Impact of bacterial infection and intestinal microbiome on colorectal cancer development被引量：2
《Chinese Medical Journal》2022年第4期400-408,共9页Jun Sun 
This study was supported by grants from UIC Cancer Center,the NIDDK/National Institutes of Health(No.R01 DK105118,R01DK114126)。
Accumulating evidence suggests that intestinal bacteria play an important role in the pathogenesis of colorectal cancer(CRC).Due to the complexity of the intestinal microbiome,identification of the specific causative ...
关键词：Adenomatous polyposis coil BETA-CATENIN Colorectal cancer MICROBIOME Post-translational modifications SALMONELLA 
Shenning II Decoction Inhibits Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells via Regulation of Wnt/<i>β</i>-Catenin Signaling被引量：1
《Open Journal of Nephrology》2020年第4期323-337,共15页Shengfang Xie Fengfeng Ge Meixiao Sheng Yuanzhang Yao Liming Fang Houcai Huang Wei Zhang 
This study was conducted to investigate the effect of Shenning II decoction on renal function, renal pathology, epithelial-to-mesenchymal transition (EMT), and Wnt/beta-catenin signaling in unilateral ureteral obstruc...
关键词：Chronic Kidney Disease Renal Fibrosis Wnt/Beta-Catenin Signaling Pathway EMT Traditional Chinese Medicine 
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