Impact of bacterial infection and intestinal microbiome on colorectal cancer development  

作　　者：Jun Sun 

机构地区：[1]Department of Medicine,College of Medicine,University of Illinois at Chicago,Chicago,IL,USA [2]Department of Microbiology/Immunology,College of Medicine,University of Illinois at Chicago,Chicago,IL,USA [3]UIC Cancer Center,University of Illinois at Chicago,Chicago,IL,USA

出　　处：《Chinese Medical Journal》2022年第4期400-408,共9页中华医学杂志（英文版）

基　　金：This study was supported by grants from UIC Cancer Center,the NIDDK/National Institutes of Health(No.R01 DK105118,R01DK114126)。

摘　　要：Accumulating evidence suggests that intestinal bacteria play an important role in the pathogenesis of colorectal cancer(CRC).Due to the complexity of the intestinal microbiome,identification of the specific causative microbial agents in CRC remains challenging,and the search for the causative microbial agents is intense.However,whether bacteria or their products can induce inflammation that results in tumorigenesis or directly causes CRC in humans is still not clear.This review will mainly focus on the progress of bacterial infection and CRC,and introduce the microbial contribution to the hallmarks of cancer.This article usesSalmonella and its chronic infection as an example to investigate a single pathogen and its role in the development of CRC,based on laboratory and epidemiological evidence.The bacterial infection leads to an altered intestinal microbiome.The review also discusses the dysfunction of the microbiome and the mechanism of host-microbial interactions,for example,bacterial virulence factors,key signaling pathways in the host,and microbial post-translational modifications in the tumorigenesis.Colonic carcinogenesis involves a progressive accumulation of mutations in a genetically susceptible host leading to cellular autonomy.Moving forward,more human data are needed to confirm the direct roles of bacterial infection in CRC development.Insights into the inhibiting infection will help to prevent cancer and develop strategies to restore the balance between host and microorganisms.

关 键 词：Adenomatous polyposis coil BETA-CATENIN Colorectal cancer MICROBIOME Post-translational modifications SALMONELLA 

分 类 号：R735.34[医药卫生—肿瘤]