Daptomycin and linezolid for severe methicillin-resistant Staphylococcus aureus psoas abscess and bacteremia:A case report and review of the literature  

作　　者：Xiao-Bing Hong Ze-Lin Yu Hong-Bo Fu Ze-Hong Cai Jie Chen 

机构地区：[1]Department of Pharmacy,The Second Affiliated Hospital of Shantou University of Medical College,Shantou 515041,Guangdong Province,China [2]Department of Pharmacology,Shantou University Medical College,Shantou 515041,Guangdong Province,China [3]Department of Pharmacy,The First Affiliated Hospital,Sun Yat-Sen University,Guangzhou 510080,Guangdong Province,China

出　　处：《World Journal of Clinical Cases》2022年第8期2550-2558,共9页世界临床病例杂志

基　　金：Supported by Shantou Medical and Health Science and Technology Program;No. SFK [2020] 66-23

摘　　要：BACKGROUND Vancomycin remains a first-line treatment drug as per the treatment guidelines for methicillin-resistant Staphylococcus aureus(MRSA)bacteremia.However,a number of gram-positive cocci have developed resistance to several drugs,including glycopeptides.Therefore,there is an urgent need for effective and innovative antibacterial drugs to treat patients with infections caused by drugresistant bacteria.CASE SUMMARY A 24-year-old male was admitted to hospital owing to lumbago,fever,and hematuria.Computed tomography(CT)results showed an abscess in the psoas major muscle of the patient.Repeated abscess drainage and blood culture suggested MRSA,and vancomycin was initiated.However,after day 10,CT scans showed abscesses in the lungs and legs of the patient.Therefore,treatment was switched to daptomycin.Linezolid was also added considering inflammation in the lungs.After 10 d of the dual-drug anti-MRSA treatment,culture of the abscess drainage turned negative for MRSA.On day 28,the patient was discharged without any complications.CONCLUSION This case indicates that daptomycin combined with linezolid is an effective remedy for bacteremia caused by MRSA with pulmonary complications.

关 键 词：BACTEREMIA DAPTOMYCIN Gram-positive cocci LINEZOLID Methicillin-resistant Staphylococcus aureus VANCOMYCIN Case report 

分 类 号：R969[医药卫生—药理学]