Spectrum of neuropsychiatric symptoms in chronic post-stroke aphasia  

作　　者：Lisa Edelkraut Diana López-Barroso María JoséTorres-Prioris Sergio E Starkstein Ricardo E Jorge Jessica Aloisi Marcelo L Berthier Guadalupe Dávila 

机构地区：[1]Department of Psychobiology and Methodology of Behavioral Science,Faculty of Psychology and Speech Therapy,University of Malaga,Malaga 29071,Spain [2]Cognitive Neurology and Aphasia Unit,Centro de Investigaciones Médico-Sanitarias,University of Malaga,Malaga 29010,Spain [3]Instituto de Investigación Biomédica de Málaga,University of Malaga,Malaga 29010,Spain [4]School of Psychiatry and Neurosciences,The University of Western Australia,Perth 6009,Australia [5]Department of Psychiatry and Behavioral Sciences,Baylor College of Medicine,Houston,TX 77030,United States

出　　处：《World Journal of Psychiatry》2022年第3期450-469,共20页世界精神病学杂志

基　　金：Supported by Ministerio de Economía,Industria y Competitividad,Instituto de Salud Carlos III,Madrid,Spain,No. PI16/01514

摘　　要：BACKGROUND Neuropsychiatric symptoms(NPS)have been insufficiently examined in persons with aphasia(PWA)because most previous studies exclude participants with language and communication disorders.AIM To report a two-part study consisting of a literature review and an observational study on NPS in post-stroke aphasia.METHODS Study 1 reviewed articles obtained from PubMed,PsycINFO,Google Scholar and Cochrane databases after cross-referencing key words of post-stroke aphasia to NPS and disorders.Study 2 examined language deficits and activities of daily living in 20 PWA(median age:58,range:28-65 years;13 men)with the Western Aphasia Battery-Revised and the Barthel Index,respectively.Informants of these 20 PWA were proxy-evaluated with the Neuropsychiatric Inventory and domain-specific scales,including the Stroke Aphasia Depression Questionnaire-10 item version and the Starkstein Apathy Scale.In addition,an adapted version of the Hospital Anxiety and Depression Scale was directly administered to the PWA themselves.This observational study is based on the baseline assessment of an intervention clinical trial(EudraCT:2017-002858-36;ClinicalTrials.gov identifier:NCT04134416).RESULTS The literature review revealed a broad spectrum of NPS in PWA,including depression,anxiety,apathy,agitation/aggression,eating and sleep disorders,psychosis,and hypomania/mania.These findings alert to the need for improving assessment and treatment approaches of NPS taking into consideration their frequent occurrence in PWA.Study 2 showed that the 20 participants had mild-to-moderate aphasia severity and were functionally independent.A wide range of comorbid NPS was found in the post-stroke aphasic population(median number of NPS:5,range:1-8).The majority of PWA(75%)had depressive symptoms,followed by agitation/aggression(70%),irritability(70%),anxiety(65%)and appetite/eating symptoms(65%).Half of them also presented symptoms of apathy,whereas euphoria and psychotic symptoms were rare(5%).Domain-specific scales revealed that 45%of participant

关 键 词：APHASIA Stroke Neuropsychiatric symptoms ANXIETY APATHY DEPRESSION 

分 类 号：R743.3[医药卫生—神经病学与精神病学]