Synthesis of rac-α-aryl propionaldehydes via branched-selective hydroformylation of terminal arylalkenes using water-soluble Rh-PNP catalyst  

作　　者：Peng Gao Miaolin Ke Tong Ru Guanfeng Liang Fen-Er Chen 

机构地区：[1]Department of Chemistry,Sichuan University,Chengdu 610064,China [2]Department of Chemistry,Fudan University,Shanghai 200433,China [3]Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs,Fudan University,Shanghai 200433,China

出　　处：《Chinese Chemical Letters》2022年第2期830-834,共5页中国化学快报（英文版）

基　　金：financial support from the National Natural Science Foundation of China (No.21902032)。

摘　　要：This work detailed the preparation of a class of water-soluble PNP ligands that differed by the nature of the substitute on phenyl ring of ligands. These ligands were incorporated into water-soluble rhodium-PNP complex catalysts that were used to regioselective hydroformylation of a series of terminal arylalkenes,providing efficient access to rac-α-aryl propionaldehydes in good to excellent yield(up to 97%) and branched-regioselectivity(up to 40:1 b/l ratio). Furthermore, gram-scale and diverse synthetic transformation demonstrated synthetic application of this methodology for non-steroidal antiinflammatory drugs.

关 键 词：Aryl propionaldehydes HYDROFORMYLATION Water-soluble PNP ligands Regioselectivity RHODIUM 

分 类 号：TQ460.1[化学工程—制药化工] TQ426