蓝莓花青素对2型糖尿病小鼠糖脂代谢的调节作用  

Regulation Effects of Blueberry Anthocyanins on Glucose-Lipid Metabolism in Type 2 Diabetic Mice

作　　者：尤丽 党娅 杨彬彦 YOU Li;DANG Ya;YANG Binyan(College of Biological Science and Engineering,Shaanxi University of Technology,Hanzhong 723000,China;Shaanxi Province Fruit Industry Administration Qinba Mountain Blueberry Research Institute,Hanzhong 723000,China;Shaanxi Provincial Key Laboratory of Resource Biology,Hanzhong 723000,China)

机构地区：[1]陕西理工大学生物科学与工程学院,陕西汉中723000 [2]陕西省果业管理局秦巴山区蓝莓研究所,陕西汉中723000 [3]陕西省资源生物重点实验室,陕西汉中723000

出　　处：《食品工业科技》2022年第9期381-388,共8页Science and Technology of Food Industry

基　　金：陕西省科技厅项目(2015SZS-15-02);陕西理工大学研究生创新基金项目(SLGYCX2016)。

摘　　要：目的:探讨蓝莓花青素(Blueberry anthocyanins,BA)对2型糖尿病小鼠糖代谢、脂代谢的调节作用。方法:采用高脂高糖饮食联合腹腔注射链佐霉素(Streptozocin,STZ)建立2型糖尿病小鼠模型,设置正常组、模型组、阳性药物组(250 mg/kg)、蓝莓花青素组(300、200、100 mg/kg)。实验期间测定小鼠的进食量、饮水量、体重和空腹血糖值(Fasting blood-glucose,FBG);连续灌胃给药4周后,分别测定小鼠葡萄糖耐量(Oral glucose tolerance test,OGTT)、糖化血红蛋白(Glycated hemoglobin,HbA1c)含量、血清胰岛素(Insulin,INS)、胰岛素抵抗指数(Homeostasis model assessment insulin resistance,HOMA-IR)和血脂相关指标。结果:与模型组小鼠相比,蓝莓花青素组可明显改善2型糖尿病小鼠多饮多食体重减轻的典型症状;改善小鼠的糖代谢水平,促进胰岛素的分泌,降低胰岛素的抵抗性;显著降低2型糖尿病小鼠的总胆固醇、甘油三酯、低密度脂蛋白胆固醇含量,增加高密度脂蛋白胆固醇含量,且呈现一定的量效关系。结论:蓝莓花青素可通过控制糖尿病小鼠血糖浓度和胰岛素抵抗性途径,抑制血脂代谢异常,起到调节相关糖尿病指标的作用。Objective:To investigate the effects of blueberry anthocyanins(BA) on glucose metabolism and lipid metabolism in type 2 diabetic mice.Methods:The mice model of type 2 diabetes mellitus was established by high-fat and high-sugar diet combined with intraperitoneal injection of streptomycin(STZ),and the normal group,model group,positive drug group(250 mg/kg) and blueberry anthocyanin group(300,200,100 mg/kg) were set up.The food intake,water intake,body weight and fasting blood glucose(FBG) of mice were measured during the experiment.Oral glucose tolerance test(OGTT),glycated hemoglobin(HbA1c),serum insulin(INS),homeostasis model assessment insulin resistance(HOMA-IR)and blood lipid related indexes of mice were determined after 4 weeks of continuous intragastric administration.Results:Compared with model group,blueberry anthocyanin group could significantly improve the typical symptoms of weight loss of type 2 diabetic mice with polydipsia,improve the glucose metabolism level of mice,promote the secretion of insulin and reduce insulin resistance.The contents of total cholesterol,triglyceride and low density lipoprotein cholesterol were significantly decreased in type 2 diabetic mice,while the contents of high density lipoprotein cholesterol were increased in a dose-effect relationship.Conclusion:Blueberry anthocyanins can inhibit dyslipidemia and regulate related diabetes indicators by controlling blood glucose concentration and insulin resistance pathway in diabetic mice.

关 键 词：蓝莓花青素 2型糖尿病 糖代谢 脂代谢 胰岛素抵抗 

分 类 号：TS202.1[轻工技术与工程—食品科学]