Respiratory flora:The potential biomarker of radiation-induced pulmonary injury  

作　　者：Hongjuan Guo Lili Wang Wei Zhu Xiaofei Qi Qi Zhang Yang Jiao Jianping Cao 

机构地区：[1]State Key Laboratory of Radiation Medicine and Protection,School of Radiation Medicine and Protection,Soochow University,Suzhou 215123,China [2]Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions,Soochow University,Suzhou 215123,China [3]Department of Radiotherapy,First Affiliated Hospital of Soochow University,Suzhou 215006,China [4]Department of Hematology,First Affiliated Hospital of Soochow University,Suzhou 215006,China

出　　处：《Radiation Medicine and Protection》2022年第1期43-46,共4页放射医学与防护（英文）

基　　金：This study was supported by the National Natural Science Foundation of China(No.81773226,U1967220,and 82073476);Key Laboratory of Radiation Medicine and Protection,Soochow University(GZN1202101);China Postdoctoral Science Foundation(No.2017M611908 and 2017M610351);Jiangsu Province Postdoctoral Science Foundation(No.1701177B).

摘　　要：Radiation-induced pulmonary injury is a major dose-limiting toxicity that occurs due to thoracic radiotherapy.And the most widely used high-throughput technology,16S ribosomal RNA sequencing,is adopted for bacterial classification and identification of airway microbiome analysis.In this study,we provide novel insights into the composition pattern and predicted function of the lung microbiome in RIPI rats.Certain genus and species change in a dose-dependent manner,which might be capable of serving as novel bacterial biomarkers,as well as the potential targets for the future diagnosis or treatment of RIPI.In summary,our findings provide a vital reference for RIPI study,and will contribute to investigate the novel therapeutic or preventive management for RIPI.

关 键 词：RIPI Mocrobiome 16S rRNA-seq DOSE-DEPENDENT BIOMARKER 

分 类 号：R563[医药卫生—呼吸系统] R81[医药卫生—内科学]