Overcoming the obstacles of current photodynamic therapy in tumors using nanoparticles  

作　　者：Donghyun Lee Soonmin Kwon Seok-young Jang Eunyoung Park Yeeun Lee Heebeom Koo 

机构地区：[1]Department of Medical Life Sciences,Department of Biomedicine&Health Sciences,and Catholic Photomedicine Research Institute,College of Medicine,The Catholic University of Korea,222 Banpo-daero,Seocho-gu,Seoul,06591,Republic of Korea

出　　处：《Bioactive Materials》2022年第2期20-34,共15页生物活性材料（英文）

基　　金：supported by Basic Research Program(2016R1C1B3013951,2021R1F1A1061286,and 2021R1A4A3031875)through the National Research Foundation of Korea(NRF)funded by the Korean government(Ministry of Science,ICT,and Future Planning).

摘　　要：Photodynamic therapy(PDT)has been applied in clinical treatment of tumors for a long time.However,insufficient supply of pivotal factors including photosensitizer(PS),light,and oxygen in tumor tissue dramatically reduces the therapeutic efficacy of PDT.Nanoparticles have received an influx of attention as drug carriers,and recent studies have demonstrated their promising potential to overcome the obstacles of PDT in tumor tissue.Physicochemical optimization for passive targeting,ligand modification for active targeting,and stimuli-responsive release achieved efficient delivery of PS to tumor tissue.Various trials using upconversion NPs,two-photon lasers,X-rays,and bioluminescence have provided clues for efficient methods of light delivery to deep tissue.Attempts have been made to overcome unfavorable tumor microenvironments via artificial oxygen generation,Fenton reaction,and combination with other chemical drugs.In this review,we introduce these creative approaches to addressing the hurdles facing PDT in tumors.In particular,the studies that have been validated in animal experiments are preferred in this review over proof-of-concept studies that were only performed in cells.

关 键 词：Photodynamic therapy NANOPARTICLE TUMOR-TARGETING Drug delivery Tissue penetration 

分 类 号：R730.5[医药卫生—肿瘤] TB383[医药卫生—临床医学]