Magnetic lipid nanovehicles synergize the controlled thermal release of chemotherapeutics with magnetic ablation while enabling non-invasive monitoring by MRI for melanoma theranostics  

作　　者：Lorena Garcia-Hevia Inigo Casafont Jessica Oliveira Nuria Teran Monica L.Fanarraga Juan Gallo Manuel Banobre-Lopez 

机构地区：[1]Advanced(Magnetic)Theranostic Nanostructures Lab.International Iberian Nanotechnology Laboratory,Avda.Mestre Jose Veiga s/n,4715-330,Braga,Portugal [2]Grupo de Nanomedicina.Universidad de Cantabria-IDIVAL,Herrera Oria s/n,39011,Santander,Spain

出　　处：《Bioactive Materials》2022年第2期153-164,共12页生物活性材料（英文）

基　　金：partially supported by NORTE 2020(2014-2020 North Portugal Regional Operational Program);the ERDF(European Regional Development Fund)under Grant NORTE-01-0145-FEDER-000019;by European Union’s Horizon 2020 Research and Innovation Programme under grant agreement No.686009;by“TAMs-targeted and externally controlled nanotheranostics of triple-negative-breast-cancer(Nanother)"project UTAP-EXPL/NTec/0038/2017;by“Local specific treatment of triple-negative-breast-cancer through externally triggered target-less drug carriers(MagtargetON)"project NORTE-01-0145-FEDER-031142;co-funded by FCT and the ERDF through NORTE2020;by 2014-2020 INTERREG Cooperation Programme Spain-Portugal(POCTEP)through the project 0624_2IQBIONEURO_6_E;support from Raman4clinics COST Action BM1401 and Radiomag COST action TD1402;the ERDF and the Spanish MINECO under project ref.PI19/00349(AES 2019);the Instituto de Salud Carlos Ⅲ for the Sara Borrell Grant(CD19/00035).

摘　　要：Nowadays,a number of promising strategies are being developed that aim at combining diagnostic and therapeutic capabilities into clinically effective formulations.Thus,the combination of a modified release provided by an organic encapsulation and the intrinsic physico-chemical properties from an inorganic counterpart opens new perspectives in biomedical applications.Herein,a biocompatible magnetic lipid nanocomposite vehicle was developed through an efficient,green and simple method to simultaneously incorporate magnetic nanoparticles and an anticancer drug(doxorubicin)into a natural nano-matrix.The theranostic performance of the final magnetic formulation was validated in vitro and in vivo,in melanoma tumors.The systemic administration of the proposed magnetic hybrid nanocomposite carrier enhanced anti-tumoral activity through a synergistic combination of magnetic hyperthermia effects and antimitotic therapy,together with MRI reporting capability.The application of an alternating magnetic field was found to play a dual role,(i)acting as an extra layer of control(remote,on-demand)over the chemotherapy release and(ii)inducing a local thermal ablation of tumor cells.This combination of chemotherapy with thermotherapy establishes a synergistic platform for the treatment of solid malignant tumors under lower drug dosing schemes,which may realize the dual goal of reduced systemic toxicity and enhanced anti-tumoral efficacy.

关 键 词：Drug delivery systems Theranosis Magnetic hyperthermia Magnetic resonance imaging MELANOMA 

分 类 号：TB383[一般工业技术—材料科学与工程] R730.5[医药卫生—肿瘤]