Multifunctional microcapsules:A theranostic agent for US/MR/PAT multi-modality imaging and synergistic chemo-photothermal osteosarcoma therapy  

作　　者：Hufei Wang Sijia Xu Daoyang Fan Xiaowen Geng Guang Zhi Decheng Wu Hong Shen Fei Yang Xiao Zhou Xing Wang 

机构地区：[1]Beijing National Laboratory for Molecular Sciences,Institute of Chemistry,Chinese Academy of Sciences,Beijing,100190,China [2]University of Chinese Academy of Sciences,Beijing,100049,China [3]Department of Orthopaedic,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000,China [4]Department of Cardiology,Chinese PLA General Hospital,Beijing,100853,China

出　　处：《Bioactive Materials》2022年第1期453-465,共13页生物活性材料（英文）

基　　金：This work is supported by the National Natural Science Foundation of China(51973226,51773004,51920105006 and 81630056);National Key Basic Research Program of China(2014CB542202);the Youth Innovation Promotion Association CAS(No.2019031)for financial support.

摘　　要：Development of versatile theranostic agents that simultaneously integrate therapeutic and diagnostic features remains a clinical urgent.Herein,we aimed to prepare uniform PEGylated(lactic-co-glycolic acid)(PLGA)microcapsules(PB@(Fe_(3)O_(4)@PEG-PLGA)MCs)with superparamagnetic Fe3O4 nanoparticles embedded in the shell and Prussian blue(PB)NPs inbuilt in the cavity via a premix membrane emulsification(PME)method.On account of the eligible geometry and multiple load capacity,these MCs could be used as efficient multi-modality contrast agents to simultaneously enhance the contrasts of US,MR and PAT imaging.In-built PB NPs furnished the MCs with excellent photothermal conversion property and embedded Fe_(3)O_(4)NPs endowed the magnetic location for fabrication of targeted drug delivery system.Notably,after further in-situ encapsulation of antitumor drug of DOX,(PB+DOX)@(Fe_(3)O_(4)@PEG-PLGA)MCs possessed more unique advantages on achieving near infrared(NIR)-responsive drug delivery and magnetic-guided chemo-photothermal synergistic osteosarcoma therapy.In vitro and in vivo studies revealed these biocompatible(PB+DOX)@(Fe_(3)O_(4)@PEG-PLGA)MCs could effectively target to the tumor tissue with superior therapeutic effect against the invasion of osteosarcoma and alleviation of osteolytic lesions,which will be developed as a smart platform integrating multi-modality imaging capabilities and synergistic effect with high therapy efficacy.

关 键 词：Multi-modality imaging MICROCAPSULE Photothermal therapy Drug delivery OSTEOSARCOMA 

分 类 号：R730.5[医药卫生—肿瘤]