A highly immunogenic live-attenuated vaccine candidate prevents SARS-CoV-2 infection and transmission in hamsters  

作　　者：Xiao-Feng Li Zhen Cui Hang Fan Qi Chen Lei Cao Hong-Ying Qiu Na-Na Zhang Yan-Peng Xu Rong-Rong Zhang Chao Zhou Qing Ye Yong-Qiang Deng Yan Guo Si Qin Kaiyue Fan Lei Wang Zijing Jia Yujun Cui Xiangxi Wang Cheng-Feng Qin 

机构地区：[1]Department of Virology,State Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology,Academy of Military Medical Sciences,Beijing 100071,China [2]CAS Key Laboratory of Infection and Immunity,National Laboratory of Macromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China [3]School of Medicine,Tsinghua University,Beijing 100084,China [4]Research Unit of Discovery and Tracing of Natural Focus Diseases,Chinese Academy of Medical Sciences,Beijing 100071,China

出　　处：《The Innovation》2022年第2期126-135,共10页创新（英文）

基　　金：This work was supported by the National Key Research and Development Program of China(No.2020YFC0840900,2018YFA0900801 and 2020YFA0707500);the Strategic Priority Research Program(XDB29010000,XDB37030000),CAS(YSBR-010);the Emergency Key Programof Guangzhou Laboratory(No.EKPG21-09);the Beijing Municipal Science and Technology Project(No.Z201100001020004,Z201100005420017);the National Natural Science Foundation of China(No.82171820,No.12034006,and No.81921005);C.-F.Q.was supported by the National Science Fund for Distinguished Young Scholars(81925025);the Innovative Research Group(81621005)from the NSFC;the Innovation Fund forMedical Sciences(2019-I2 M-5-049)from the Chinese Academy of Medical Sciences.

摘　　要：The highly pathogenic and readily transmissible SARS-CoV-2 has caused a global coronavirus pandemic,urgently requiring effective countermeasures against its rapid expansion.All available vaccine platforms are being used to generate safe and effective COVID-19 vaccines.Here,we generated a live-attenuated candidate vaccine strain by serial passaging of a SARSCoV-2 clinical isolate in Vero cells.

关 键 词：VACCINE ATTENUATED INFECTION 

分 类 号：R37[医药卫生—病原生物学]