Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer  

作　　者：Lifo Ruan Jun Chen Chuanchao Du Huiru Lu Jiayu Zhang Xiaomeng Cai Rui Dou Wenchu Lin Zhifang Chai Guangjun Nie Yi Hu 

机构地区：[1]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,Multi-disciplinary Research Division,Institute of High Energy Physics,Chinese Academy of Sciences(CAS),Beijing,100049,PR China [2]University of Chinese Academy of Sciences,Beijing,100049,PR China [3]Peking University Third Hospital,Beijing,100191,PR China [4]High Magnetic Field Laboratory,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei,230031,Anhui,PR China [5]University of Science and Technology of China,Hefei,230026,Anhui,PR China [6]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology,Beijing,100190,PR China

出　　处：《Bioactive Materials》2022年第7期191-199,共9页生物活性材料（英文）

基　　金：We are grateful to Beijing Natural Science Foundation(7212212);National Natural Science Foundation of China(11875269 and 21574136);Hundred Talents Program of CAS for financial support。

摘　　要：Reversal of cancer drug resistance remains a critical challenge in chemotherapy.Mitochondria-targeted drug delivery has been suggested to mitigate drug resistance in cancer.To overcome the intrinsic limitations in conventional mitochondrial targeting strategies,we develop mitochondrial temperature-responsive drug delivery to reverse doxorubicin(DOX)resistance in lung cancer.Results demonstrate that the thermoresponsive nanocarrier can prevent DOX efflux and facilitate DOX accumulation and mitochondrial targeting in DOX-resistant tumors.As a consequence,thermoresponsive nanocarrier enhances the cytotoxicity of DOX and reverses the drug resistance in tumor-bearing mice.This work represents the first example of mitochondrial temperature-responsive drug delivery for reversing cancer drug resistance.

关 键 词：Mitochondrial temperature THERMORESPONSIVE Drug delivery Drug resistance NANOMEDICINES 

分 类 号：R73[医药卫生—肿瘤]