Prothrombin kringle-2, a mediator of microglial activation: new insight in Alzheimer’s disease pathogenesis  

作　　者：Jae Man Lee Sang Ryong Kim 

机构地区：[1]Department of Biochemistry and Cell Biology,Cell and Matrix Research Institute,School of Medicine,Kyungpook National University,Daegu,Korea [2]Brain Science and Engineering Institute,Kyungpook National University,Daegu,Korea [3]School of Life Sciences,BK21 FOUR KNU Creative BioResearch Group,Institute of Life Science and Biotechnology,Kyungpook National University,Daegu,Korea

出　　处：《Neural Regeneration Research》2022年第12期2675-2676,共2页中国神经再生研究（英文版）

基　　金：supported by the National Research Foundation of Korea(NRF-2020R1A2C2007954);the Korea Healthcare Technology R&D(HI21C1795)grants funded by the Korean government

摘　　要：Microglial activation in Alzheimer’s disease(AD):In 1907,Dr.Alois Alzheimer,a Bavarian-born German psychiatrist and neuropathologist,published an article describing the clinical and neuropathological features of an unclassified psychiatric disorder.The disorder was later named AD and is currently the most common brain disorder(Takata et al.,2021).AD involves the accumulation of amyloid-β(Aβ)and hyperphosphorylated tau proteins in the brain,which are associated with senile plaques and neurofibrillary tangles,respectively(Vergara et al.,2019;Takata et al.,2021).AD is characterized by cognitive impairment and memory loss with hippocampal neurodegeneration(Kim et al.,2021).

关 键 词：ALZHEIMER Aβ tau 

分 类 号：R749.16[医药卫生—神经病学与精神病学]