Resolving the age-related decline in central nervous system myelin turnover and drug discovery for oligodendroglial rejuvenation  

作　　者：Andrea Domenico Rivera Arthur Morgan Butt Kasum Azim 

机构地区：[1]Institute of Biomedical and Biomolecular Sciences,School of Pharmacy and Biomedical Science,University of Portsmouth,Portsmouth,UK [2]Section of Human Anatomy,Department of Neuroscience,University of Padua,Padua,Italy [3]Department of Neurology,Medical Faculty,Heinrich-Heine-University,Düsseldorf,Germany

出　　处：《Neural Regeneration Research》2022年第12期2677-2678,共2页中国神经再生研究（英文版）

基　　金：supported by a PhD Studentship from The Anatomical Society(to ADR, AMB);grants from the BBSRC(to AMB, ADR, Grant Number BB/M029379/1);MRC(to AMB, Grant Number MR/P025811/1);Multiple Sclerosis Society of the UK(to AMB;Award Reference:40 );MSCA Seal of Excellence@UNIPD;NVIDIA Hardware Grant(to ADR);German Research Council(AZ/115/1-1;AZ/115/1-3);Swiss National Funds(to KA;P300PA_171224)

摘　　要：Myel i n genes are amongst the most dysregulated genes in the aged brain:Just over half of the weight of an entire adult human brain is attributed to myelin,which wraps around neuronal axons and is essential for superfast axonal conduction and neuronal integrity.In the central nervous system,it is the function of specialized cells called oligodendrocytes(OLs)to make myelin,which is made up of lipids and proteins.OLs are generated throughout life by a significant population of oligodendrocyte progenitor cells(OPCs)that are responsible for the lifelong generation of OLs and myelin,essential for learning,as well as repair following pathological insults(i.e.in demyelinating diseases that include multiple sclerosis)(Simons and Nave,2015;Philips and Rothstein,2017).Changes in myelin content in the human brain over the lifespan of individuals have been well documented,as well as evidence of myelin loss in rodent models using classical histological approaches(Bartzokis et al.,2012;Soreq et al.,2017).

关 键 词：MYELIN SYSTEM specialized 

分 类 号：R741[医药卫生—神经病学与精神病学]