Comparison between sodium iodate and lipid peroxide murine models of age-related macular degeneration for drug evaluation-a narrative review  

作　　者：Soo-Young Kim Haohua Qian 

机构地区：[1]Department of Pharmaceutics,Department of Biology,Virginia Commonwealth University,Richmond,VA,USA [2]Center for Nanomedicine,Wilmer Eye Institute,Department of Ophthalmology,Johns Hopkins University of Medicine,Baltimore,MD,USA [3]Visual Function Core,National Eye Institute,National Institutes of Health,Bethesda,MD,USA

出　　处：《Annals of Eye Science》2022年第1期86-105,共20页眼科学年鉴（英文）

摘　　要：Objective:In this review,non-transgenic models of age-related macular degeneration(AMD)are discussed,with focuses on murine retinal degeneration induced by sodium iodate and lipid peroxide(HpODE)as preclinical study platforms.Background:AMD is the most common cause of vision loss in a world with an increasingly aging population.The major phenotypes of early and intermediate AMD are increased drusen and autofluorescence,Müller glia activation,infiltrated subretinal microglia and inward moving retinal pigment epithelium(RPE)cells.Intermediate AMD may progress to advanced AMD,characterized by geography atrophy and/or choroidal neovascularization(CNV).Various transgenic and non-transgenic animal models related to retinal degeneration have been generated to investigate AMD pathogenesis and pathobiology,and have been widely used as potential therapeutic evaluation platforms.Methods:Two retinal degeneration murine models induced by sodium iodate and HpODE are described.Distinct pathological features and procedures of these two models are compared.In addition,practical protocol and material preparation and assessment methods are elaborated.Conclusions:Retina degeneration induced by sodium iodate and HpODE in mouse eye resembles many clinical aspects of human AMD and complimentary to the existent other animal models.However,standardization of procedure and assessment protocols is needed for preclinical studies.Further studies of HpODE on different routes,doses and species will be valuable for the future extensive use.Despite many merits of murine studies,differences between murine and human should be always considered.

关 键 词：Retina degeneration retinal pigment epithelium(RPE) PHOTORECEPTOR MICROGLIA 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]