supported by the National Natural Science Foundation of China,Nos. 82171076 (to XS) and U22A20311 (to XS), 82101168 (to TL);Shanghai Science and technology Innovation Action Plan,No. 23Y11901300 (to JS);Science and Technology Commission of Shanghai Municipality,No. 21ZR1451500 (to TL);Shanghai Pujiang Program,No. 22PJ1412200 (to BY)。
Progressive photoreceptor cell death is one of the main pathological features of age-related macular degeneration and eventually leads to vision loss. Ferroptosis has been demonstrated to be associated with retinal de...
supported by the National Natural Science Foundation of China(32330009,32000155).
The functions of photoreceptors have been extensively investigated over the last two decades.However,whether those photoreceptors have any functions in the absence of light remained unclear.Recently,Prof.Hongtao Liu’...
supported by the Start-up Fund for new faculty from the Hong Kong Polytechnic University(PolyU)(A0043215)(to SA);the General Research Fund and Research Impact Fund from the Hong Kong Research Grants Council(15106018,R5032-18)(to DYT);the Research Center for SHARP Vision in PolyU(P0045843)(to SA);the InnoHK scheme from the Hong Kong Special Administrative Region Government(to DYT).
Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecu...
supported by the State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-Sen University,Guangzhou,China;the National Key R&D Program of China(2023YFC2506100 to X.L.);the National Natural Science Foundation of China(82150710555 and 82220108016 to X.L.);the Natural Science Foundation of Guangdong Province grant(2021A1515010684 to W.L.);the Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science(2020B1212060033 to W.L.),and the Guangzhou Basic Research Program(2023A03J0182 to W.L.).
The retinal pigment epithelium(RPE)between retinal photoreceptors and choroidal capillaries is a single layer of cells that are of critical importance to the eye.RPE cells are derived from the anterior neural plate of...
Supported by National Natural Science Foundation of China(No.81900862)。
AIM:To investigate the involvement of pericyte-Müller glia interaction in retinal damage repair and assess the influence of suppressing the platelet-derived growth factor receptorβ(PDGFRβ)signaling pathway in retin...
Supported by the National Key R&D Project(No.2018YFC1106103);Project of Sichuan Medical Association(No.S22058).
AIM:To study the effect of the NLRP3/autophagy pathway on the photoreceptor inflammatory response and the protective mechanism of CY-09 and astaxanthin(AST).METHODS:ICR mice were intraperitoneally injected NaIO_(3),CY...
Retinitis pigmentosa(RP)is a group of genetic disorders characterized by progressive degeneration of photoreceptors and retinal pigment epithelium(RPE)cells.Its main clinical manifestations include night blindness and...
As one of the most important environmental signals for plants,light plays a profound role in regulating virtually every aspect of plant growth and development.Light signals are perceived by plants via several families...
supported by The National Natural Science Foundation of China(No.82121003,81970841,82101160);the program of Science and Technology International Cooperation Project of Qinghai province(China)(No.2022-HZ-814);the CAMS Innovation Fund for Medical Sciences(No.2019-12M-5-032);Sichuan Intellectual Property Office(China)(No.2022-ZS-0070);the Department of Chengdu Science and Technology(Sichuan,China)(No.2021-YF05-01316-SN).
The endoplasmic reticulum(ER)membrane protein complex(EMC)is responsible for monitoring the biogenesis and synthetic quality of membrane proteins with tail-anchored or multiple transmembrane domains.The EMC subunit EM...
supported by the Natural Science Foundation of Jiangsu for Distinguished Young Scholars (BK20211525);the National Natural Science Foundation of China (32270256,31970258);the Core Technology Development for Breeding Program of Jiangsu Province (JBGS-2021-014);the Jiangsu Collaborative Innovation Center for Modern Crop Production (to D.X.);Nanjing Agricultural University (start-up funding to D.X.).
Isoflavonoids,secondary metabolites derived from the phenylalanine pathway,are predominantly bio-synthesized in legumes,especially soybean(Glycine max).They are not only essential for plant responses to biotic and abi...