Altering the intestinal microbiota for therapeutic benefit in uveitis  

作　　者：Phoebe Lin 

机构地区：[1]Casey Eye Institute,Oregon Health&Science University,Portland,OR,USA

出　　处：《Annals of Eye Science》2020年第3期50-55,共6页眼科学年鉴（英文）

基　　金：This study was supported by a National Eye Institute Grant K08 EY022948,a Collins Medical Trust Grant,and a Research to Prevent Blindness Career Development Award(PL);This study was also supported by core grant P30 EY010572 from the National Institute of Health(Bethesda,MD)and by unrestricted departmental funding from Research to Prevent Blindness(New York,NY).PL is also the recipient of an Alcon Research Institute Young Investigator Award and OHSU Physician-Scientist award,as well as recipient of a Thome Foundation award.

摘　　要：An intestinal dysbiosis is connected to a number of inflammatory diseases through various mechanisms relating to its effect on immune cell function and differentiation.This is a review of the literature summarizing our current understanding of intestinal microbial contributions to non-infectious uveitis and strategies to target the intestinal microbiome to treat uveitis.Several groups have demonstrated an intestinal dysbiosis associated with certain types of non-infectious uveitis.Additionally,approaches to treat uveitis by modifying the intestinal microbiota,such as oral antibiotics or administration of oral short chain fatty acids(SCFAs),which are intestinal bacterial metabolites produced by fermentation of dietary fiber,can successfully treat uveitis in mouse models.This reduction in severity of ocular inflammation occurs via the following mechanisms:enhancement of regulatory T cells,decreasing intestinal permeability,and/or affecting T cell trafficking between the intestines and the spleen.Other strategies that are directed at the intestinal microbiota that might be effective to treat uveitis include dietary changes,probiotics,or fecal microbial transplantation.The commensal gut bacteria are influential in systemic and intestinal mucosal immunity and thus contribute to the development of extraintestinal inflammation like uveitis.Targeting the intestinal microbiome thus has the potential to be a successful strategy to treat non-infectious uveitis.

关 键 词：Non-infectious uveitis MICROBIOME short chain fatty acids(SCFAs) 

分 类 号：R57[医药卫生—消化系统]