AB035.The link between cognitive impairment and drusen quantity in age-related macular degeneration  

作　　者：Stephanie Pietrangelo Caitlin Murphy Sophie Hallot Aaron Johnson 

机构地区：[1]Department of Psychology,Concordia University,Montréal,QC,Canada [2]CRIR/Centre de réadaptation MAB-Mackay du CIUSSS du CentreOuest-de-l’Île-de-Montréal,Montreal,QC,Canada

出　　处：《Annals of Eye Science》2019年第1期210-210,共1页眼科学年鉴（英文）

摘　　要：Background:Age-related macular degeneration(AMD)is a common cause of severe vision impairment in populations over 50 years old.It is characterized by drusen;the accumulation of waste between the retinal pigment epithelium and Bruch’s membrane.Drusen have been identified in the eyes of Alzheimer’s patients,post-mortem.Further,beta-amyloid,best known as a pathological component of the senile plaques in Alzheimer’s disease,has been identified as a component of drusen in AMD.Researchers have also demonstrated an increased prevalence of cognitive impairment in individuals with AMD.The current study uses optical coherence tomography(OCT)and a cognitive assessment to investigate the potential use of drusen as a biomarker of cognitive impairment.The overall number of drusen detectable on the OCT scans of individuals who exhibit mild cognitive impairment is compared to the number of drusen detectable on the OCT scans of individuals who do not exhibit mild cognitive impairment.Methods:To date,10 participants(nine women)aged 74 to 95 years with a diagnosis of AMD and/or drusen have been recruited.The Optos®OCT/SLO imaging system was used to take cross-sectional images of the retina.The images were then manually graded by two trained graders to determine the number of drusen present along the retina.The Montreal Cognitive Assessment(MoCA)was used to assess overall cognitive status.Results:Of the 10 participants,three passed the full MoCA(i.e.scored at or above 26 out of 30 possible points)and seven did not pass,scoring positive for mild cognitive impairment(Mpass=27.33,SDpass=0.58;Mfail=21.86,SDfail=2.55).Preliminary analyses have demonstrated that individuals who pass the MoCA seem to have fewer drusen present overall(Mdn=35)compared to those who score positive for cognitive impairment(Mdn=63).However,a Mann-Whitney U test revealed that these findings are not significant;U=5,P=0.27.Conclusions:The results agree with previous literature demonstrating an increased prevalence of mild cognitive impairment in individuals

关 键 词：Age-related macular degeneration(AMD) DRUSEN cognitive impairment AGING 

分 类 号：R74[医药卫生—神经病学与精神病学]