眼眶静脉畸形发病机制研究进展  

Update in pathogenesis of orbital venous malformations

作　　者：杨依迪 李甬芸 贾仁兵[1,2] Yang Yidi;Li Yongyun;Jia Renbing(Department of Ophthalmology,The Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine;Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院眼科 [2]上海市眼眶病眼肿瘤重点实验室,200011

出　　处：《临床眼科杂志》2022年第2期186-190,共5页Journal of Clinical Ophthalmology

基　　金：国家自然科学基金面上项目(81770961)。

摘　　要：眼眶静脉畸形(OVM)是成人最常见的眼部脉管畸形,可导致患者外观和视力损害。TIE2、PI3KCA等基因突变与信号传导通路异常激活,使血管内皮细胞和多种细胞外基质蛋白结构异常,与静脉畸形的发生密切相关。本文通过对基因突变、信号通路在静脉畸形发生中的作用进行回顾,系统总结静脉畸形的发病机制研究。Orbital venous malformations are the most common ocular vascular malformations in adults,which can cause damage to patient's appearance and vision.TIE2,PI3KCA and other gene mutations and abnormal activation of signal transduction pathways cause abnormal structure in vascular endothelial cells and a variety of extracellular matrix proteins,which are closely related to the occurrence of venous malformations.This article reviews the role of gene mutations and signal pathways in the occurrence of venous malformations,and systematically summarizes the research on the pathogenesis of venous malformations.

关 键 词：眼眶静脉畸形 发病机制 基因突变 

分 类 号：R777.5[医药卫生—眼科]