双相情感障碍患者抗氧化物的性别差异分析  

Gender differences of antioxidants in patients with bipolar disorder

作　　者：郭伟坚[1] 熊翔 李荷花[1] 黄园园[1] 吴逢春[1,3] GUO Weijian;XIONG Xiang;LI Hehua(The Affiliated Brain Hospital of Guangzhou Medical University,Guangzhou 510370,China)

机构地区：[1]广州医科大学附属脑科医院,广州510370 [2]贵州省第二人民医院 [3]广东省精神疾病转化医学工程技术研究中心

出　　处：《国际精神病学杂志》2022年第2期199-202,共4页Journal Of International Psychiatry

基　　金：广东省中医药卫生科技项目(编号:20211306)。

摘　　要：目的探讨双相情感障碍(bipolar disorder,BD)患者抗氧化物的性别差异。方法根据性别将BD患者分男性96例和女性31例两组,对临床资料和抗氧化物指标进行数据统计。结果治疗前两组患者尿酸、白蛋白、超氧化物歧化酶(superoxide dismutase,SOD)和情绪稳定剂、抗抑郁药的使用上差异有统计学意义(P<0.05),治疗后女性患者尿酸升高水平大于男性(F=13.98,P<0.01),女性白蛋白降低水平大于男性(F=6.46,P=0.01),治疗后尿酸与性别、抗抑郁药呈负相关,白蛋白与性别、年龄、情绪稳定剂呈负相关,SOD与年龄呈负相关。结论BD患者治疗前后的抗氧化物存在性别差异。Objective To explore the gender differences of antioxidants in patients with bipolar disorder(BD).Methods According to gender,BD patients were divided into 96 males and 31 females.Clinical data and antioxidant indicators were collected and statistically analyzed.Results There was significant difference in the use of uric acid,albumin,superoxide dismutase(SOD),mood stabilizer and antidepressants between the two groups before treatment(P<0.05).After treatment,the increase level of uric acid in female patients was higher than that in male patients(F=13.98,P<0.01),and the decrease level of albumin in female patients was higher than that in male patients(F=6.46,P=0.01).After treatment,uric acid was negatively correlated with gender and antidepressants,albumin was negatively correlated with gender,age and mood stabilizer,and SOD was negatively correlated with age.Conclusion There were gender differences in antioxidants in BD patients before and after treatment.

关 键 词：双相情感障碍 性别 抗氧化物 差异 

分 类 号：R749.4[医药卫生—神经病学与精神病学]