主要宏观营养素摄入与血脂及血尿酸的相关性探析  

Correlation of the intake of major macronutrients with serum lipid and uric acid

作　　者：王丽霞[1] 韩拓 王怡雯 范雅洁 巩红 郑阳[1] 马维冬 姚智会 王聪霞[1] WANG Lixia;HAN Tuo;WANG Yiwen;FAN Yajie;GONG Hong;ZHENG Yang;MA Weidong;YAO Zhihui;WANG Congxia(Department of Cardiology,The Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710004,China;Department of Health Management,The Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710004,China)

机构地区：[1]西安交通大学第二附属医院心血管内科,陕西西安710004 [2]西安交通大学第二附属医院健康管理部,陕西西安710004

出　　处：《西安交通大学学报（医学版）》2022年第3期337-342,共6页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：国家自然科学基金资助项目(No.81273878);陕西省自然科学基金青年项目(No.2021JQ-409)。

摘　　要：目的 探究人群中不同营养素摄入与血脂、血尿酸之间的相关性。方法 基于中国健康与营养调查(CHNS2009)数据,通过ID匹配人口学资料、血清学检测及膳食营养调查结果,最终纳入1 343例人群样本,比较不同性别组间的日平均总能量、蛋白质、脂肪与碳水化合物等不同营养素摄入四分位数不同组间(由低到高分为Q1~Q4组)的血脂、血尿酸差异并进行相关性分析。结果 男性中总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)及血尿酸均显著高于女性,高密度脂蛋白胆固醇(HDL-C)则显著降低。男性的日平均能量摄入、碳水化合物、脂肪及蛋白摄入量均高于女性。不同营养素摄入四分位数的不同组间比较及相关性分析显示,总能量摄入和蛋白摄入量均与TG正相关(r=0.070 9,P=0.008 4;r=0.051 7,P=0.012 3),而脂肪摄入量与TC正相关(r=0.086 1,P=0.001 4);血尿酸水平与脂肪、蛋白摄入量呈显著正相关(r=0.127 3,P<0.001;r=0.138 0,P<0.001)。不同性别亚组分析,男性中分析结果与总体人群一致;女性中碳水化合物摄入则与血尿酸水平呈显著负相关性(r=-0.107 9,P=0.002 2)。多因素线性回归分析表明,TC、TG及血尿酸与性别、年龄及不同营养素摄入之间存在相关性。结论 男性中血尿酸及血脂异常水平显著高于女性,不同类型的血脂异常和尿酸升高与营养素摄入及性别、年龄有着不同相关关系。Objective To explore the correlation of the intake of different nutrients with the levels of serum lipids and uric acid. Methods Based on the data of China Health and Nutrition Survey(CHNS2009), a total of 1 343individuals were finally included by ID matching with demographic data,serological tests and dietary nutrition results. We compared serum lipids and uric acid levels between groups of different nutrients intake(group Q1-Q4)and conducted the correlation analysis. Results The total cholesterol(TC),triglyceride(TG),and low-density lipoprotein(LDL-C)in the men were significantly higher than those in the women,while high-density lipoprotein(HDL-C)was significantly lower in the men. The average intakes of daily energy,carbohydrate,fat and protein were significantly higher in the males than in the females. Intergroup comparisons and correlation analyses showed that total energy and protein intakes were positively correlated with TG(r=0. 070 9,P=0. 008 4;r=0. 051 7,P=0. 012 3), while fat intake was positively correlated with TC(r=0. 086 1,P=0. 001 4). The blood uric acid level was positively correlated with the intake of fat and protein(r=0. 127 3,P<0. 001;r=0. 138 0,P<0. 001). The results of subgroup analysis of the males were consistent with those of the whole population. However,there was a significantly negative correlation between carbohydrate intake and blood uric acid level in the females(r=-0. 107 9,P=0. 002 2). Multiple linear regression analysis showed that TC, TG and uric acid were correlated with gender, age and intake of different nutrients. Conclusion The levels of blood uric acid and lipids are significantly higher in men than in women. Different types of dyslipidemia and hyperuricemia are related to different nutrient intakes in different genders and ages.

关 键 词：血脂异常 高尿酸血症 碳水化合物 脂肪 蛋白质 营养素 

分 类 号：R589.2[医药卫生—内分泌]