Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma  

作　　者：Yiyi Xi Yuan Lin Wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng Zhou Jianzhong Su Chen Wu Dongxin Lin 

机构地区：[1]Department of Etiology and Carcinogenesis,National Cancer Center/National Clinical Research Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China [2]Beijing Advanced Innovation Center for Genomics,Biomedical Pioneering Innovation Center,Peking University,Beijing 100871,China [3]Cancer Institute,Affiliated Cancer Hospital of Xinjiang Medical University,Urumqi 830000,China [4]School of Biomedical Engineering,School of Ophthalmology and Optometry and Eye Hospital,Wenzhou Medical University,Wenzhou 325011,China [5]Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou 325000,China [6]Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine,Nanjing Medical University,Nanjing 211166,China [7]CAMS Key Laboratory of Genetics and Genomic Biology,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China [8]Sun Yat-sen University Cancer Center,State Key Laboratory of Oncology in South China,Guangzhou 510060,China

出　　处：《Signal Transduction and Targeted Therapy》2022年第3期896-908,共13页信号转导与靶向治疗（英文）

基　　金：Supported by National Natural Science Foundation of China(81988101 to D.L.and C.W.);National Science Fund for Distinguished Young Scholars(81725015 to C.W.);Chinese Academy Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-013 to D.L.,C.W.and W.T.,2019-I2M-2-001 to D.L and C.W.);Beijing Outstanding Young Scientist Program(BJJWZYJH01201910023027 to C.W.);the National Key R&D Program of China(2021YFC2502000 to Y.L.).

摘　　要：This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns.

关 键 词：ESOPHAGEAL SQUAMOUS diagnosis 

分 类 号：R735.1[医药卫生—肿瘤]