BRAF突变与甲状腺乳头状癌临床病理学特征关系研究  

Relationship between BRAF mutation and clinicopathological characteristics in papillary thyroid carcinoma

作　　者：王培顺[1] 李淑琴[1] 王岩[1] 汪瑞[1] 高希涛[1] 王昭昕[1] 周军[1] WANG Pei-shun;LI Shu-qin;WANG Yan;WANG Rui;GAO Xi-tao;WANG Zhao-xin;ZHOU Jun(Deparment of Thyroid and Breast Surgery,The First People′s Hospital of Lianyungang,Jiangsu 222002,China)

机构地区：[1]连云港市第一人民医院甲乳外科,江苏连云港222002

出　　处：《岭南现代临床外科》2022年第2期134-137,142,共5页Lingnan Modern Clinics in Surgery

摘　　要：目的 探讨BRAF基因在甲状腺乳头状癌(PTC)中的突变率,及其与临床病理学特征的关系。方法 选取2018年1月至2019年12月经手术治疗的253例甲状腺乳头状癌患者作为研究对象,分析BRAF基因突变与甲状腺乳头状癌患者临床病理学特征的关系。结果 81%的PTC患者中发现有BRAF基因的突变。BRAF突变率随着年龄的增长而增加,BRAF突变与PTC的淋巴转移以及临床分期间比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示年龄≥45岁、高肿瘤分期、区域淋巴结转移是BRAF突变的独立影响因素(均P<0.05)。结论 BRAF基因突变与PTC淋巴结转移、临床分期相关,而且对于甲状腺肿瘤良恶性的诊断具有重要价值。Objective clinicopathological characteristics in patients with PTC.Methods carcinoma who underwent surgery in the department of thyroid and breast surgery of the First People′s Hospital of Lianyungang from January 2018 to December 2019 were selected.The relation between the mutation of BRAF and clinicopathological features of papillary thyroid carcinoma patients was analyzed.Results mutation increased with age.There were significant correlations between BRAF mutation and lymph node metastasis,and between BRAF mutation and the clinical stage of papillary thyroid cancer(P<0.05).Multivariate Logistic regression analysis showed that ≥45 years older,high clinical stage and lymph node metastasis were independent factors for BRAF mutation.ConclusionThe mutation of BRAF is associated with the lymph node metastasis,and clinical stage of PTC,and may have a positive predictive value for diagnosing thyroid tumors.

关 键 词：甲状腺乳头状癌 BRAF 突变 临床病理性特征 

分 类 号：R736.1[医药卫生—肿瘤]