Gangliosides in nervous system development,regeneration,and pathologies  

作　　者：Juliana F.Vasques Renata Guedes de Jesus Gonçalves Almir Jordão da Silva-Junior Robertta Silva Martins Fernanda Gubert Rosalia Mendez-Otero 

机构地区：[1]Instituto de Ciências Biomédicas,Universidade Federal do Rio de Janeiro,Rio de Janeiro,Brazil [2]Instituto de Biofísica Carlos Chagas Filho,Universidade Federal do Rio de Janeiro,Rio de Janeiro,Brazil [3]Programa Redes de Pesquisa em Saúde no Estado do Rio de Janeiro,Rio de Janeiro,Brazil [4]Programa Rede NanoSaúde do Estado do Rio de Janeiro,Rio de Janeiro,Brazil [5]Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa,Rio de Janeiro,Brazil

出　　处：《Neural Regeneration Research》2023年第1期81-86,共6页中国神经再生研究（英文版）

基　　金：supported by grants and fellowships from the Departamento de Ciência e Tecnologia(DECIT/MS)do Ministério da Saúde,Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq);Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa,Fundação de AmparoàPesquisa do Estado do Rio de Janeiro(FAPERJ)(to RMO).

摘　　要：Gangliosides,sialic acid-containing sphingolipids,are major constituents of neuronal membranes.According to the number of sialic acids and the structure of the oligosaccharide chain,gangliosides can be classified as simple or complex and grouped in different ganglio-series.Hundreds of gangliosides have been identified in vertebrate cells,with different expression patterns during development and related to several physiological processes,especially in the nervous system.While GD3 and its O-acetylated form,9acGD3,are highly expressed in early developmental stages,GM1,GD1a,GD1b,and GT1b are the most abundant ganglioside species in the mature nervous system.Mutations in enzymes involved in ganglioside metabolism can lead to the accumulation of specific species,a condition termed gangliosidosis and usually marked by severe neurological impairment.Changes in ganglioside levels have also been described in several neurodegenerative diseases,such as Alzheimer’s and Parkinson’s.In this review,we summarized recent information about the roles of GD3,9acGD3,GM1,GD1a,GD1b,GT1b,and other ganglioside species in nervous system development and regeneration,as well as clinical trials evaluating possible therapeutic applications of these molecules.

关 键 词：9acGD3 GANGLIOSIDES GD1a GD1b GD3 GLYCOLIPIDS GM1 GM2 GM3 GM4 GT1b 

分 类 号：R741[医药卫生—神经病学与精神病学]