Potential roles of functional bacterial amyloid proteins,bacterial biosurfactants and other putative gut microbiota products in the etiopathogeny of Parkinson’s Disease  

作　　者：EMILIA MANOLE LAURA DUMITRESCU CRISTINA NICULIȚE BOGDAN OVIDIU POPESCU LAURA CRISTINA CEAFALAN 

机构地区：[1]Victor Babeș”National Institute of Pathology,Bucharest,050088,Romania [2]Colentina Clinical Hospital,Bucharest,020125,Romania [3]Carol Davila”University of Medicine and Pharmacy,Bucharest,020021,Romania

出　　处：《BIOCELL》2021年第1期1-16,共16页生物细胞（英文）

基　　金：was supported by the Ministry of Research and Innovation in Romania,under Grants No.PN 1N/2019_19.29.02.01,No.7PFE/2018.

摘　　要：An increasing number of studies provide evidence for the existence of a microbiota-gut-brain axis and its potential involvement in the development of sporadic Parkinson’s disease and other neurodegenerative conditions.The neuropathologic hallmark of Parkinson’s disease is the presence of brain intraneuronal aggregates of misfolded alpha-synuclein,known as Lewy bodies.Some gut microbiota products may trigger alpha-synuclein conformational changes in the neurons of the enteric nervous system,which can then spread to the brain in a prion-like fashion through the vagus nerve.Others may interfere with neuroinflammatory pathways and susceptibility to neurodegeneration.In this review,we assess the potential role of putative gut microbiota products in the etiopathogeny of Parkinson’s disease,with a special emphasis on functional bacterial amyloid proteins,bacterial biosurfactants,endotoxins and short-chain fatty acids.The possible roles of molecular hydrogen,a common byproduct of bacterial fermentation,are also addressed.

关 键 词：ALPHA-SYNUCLEIN ENDOTOXINS Short-chain fatty acids 

分 类 号：R74[医药卫生—神经病学与精神病学]