宫腔微生物与女性生殖健康疾病的关系  

Relationship of Uterine Microbiota and Female Reproductive Healthy Diseases

作　　者：张明玮 漆倩荣[1] 谢青贞(审校)[1] ZHANG Ming-wei;QI Qian-rong;XIE Qing-zhen(Center for Reproductive Medicine,Renmin Hospital of Wuhan University,Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院生殖医学中心,湖北省辅助生殖与胚胎发育医学临床研究中心,430060

出　　处：《国际生殖健康／计划生育杂志》2022年第3期214-218,共5页Journal of International Reproductive Health/Family Planning

基　　金：湖北省重点研发计划项目(2021BCA107)。

摘　　要：近年,应用二代测序和微生物组学技术证实,宫腔内存在独特的微生物菌群定植,宫腔微生物的变化不仅与生理因素有关,更与女性生殖健康疾病密切相关。然而,对宫腔核心微生物组成以及宿主-微生物间的关系仍未阐明。宫腔内微生物菌群紊乱与慢性子宫内膜炎症、胚胎反复植入失败、子宫内膜异位症和宫腔粘连等生殖系统疾病的发生、发展有关,但对于宫腔微生态失调的评估方案及纠正菌群紊乱的最佳治疗方案仍未达成共识。研究发现,经阴道给予益生菌/益生元可在一定程度上辅助治疗宫腔内微生物紊乱,改善妊娠结局。综述宫腔微生物及其与女性生殖健康状态的关系。The microbiota colonizing in the uterine cavity has been demonstrated by next-generation sequencing and microbiome technology in recent years.The changes of uterine microbiota are connected not only with physiological factors,but also with female reproductive healthy diseases.However,the core composition of uterine microbiota and the relationship between the host and the microbiota still remain unknown.The disorder of uterine microbiota could be related to the pathogenesis and pathophysiology of chronic endometritis,recurrent implantation failure,endometriosis and intrauterine adhesion,etc.However,there is not a consensus on the unified protocol to assess the dysbiosis of uterine microbiota and the optimal treatment protocol to adjust above dysbiosis.To some extent,probiotics or prebiotics using in vagina can assist to treat the dysbiosis of uterine microbiota and to improve the pregnancy outcome.In this review,we discussed the uterine microbiota and its relationship with female reproductive health.

关 键 词：宫腔 微生物群 子宫内膜炎 子宫内膜异位症 组织黏连 妊娠结局 胚胎植入 治疗 

分 类 号：R711[医药卫生—妇产科学]