Dehydrative Beckmann rearrangement and the following cascade reactions  

作　　者：Yongjiao Wei Yinghui Liu Lan-Gui Xie 

机构地区：[1]School of Chemistry and Materials Science,Jiangsu Collaborative Innovation Center of Biomedical Functional Materials,Nanjing Normal University,Nanjing 210023,China [2]College of Life Sciences,Nanjing Normal University,Nanjing 210023,China

出　　处：《Chinese Chemical Letters》2022年第5期2407-2410,共4页中国化学快报（英文版）

基　　金：supported by National Key Research and Development Project (No. 2021YFC2100100);National Natural Science Foundation of China (No. 21901123);Natural Science Foundation of Jiangsu Province (No. BK20190694);Jiangsu Specially Appointed Professor Plan

摘　　要：The Beckmann rearrangement has been predominantly studied for the synthesis of amide and lactam.By strategically using the in situ generated Appel’s salt or Mitsunobu’s zwitterionic adduct as the de-hydrating agent,a series of Beckmann rearrangement and following cascade reactions have been devel-oped herein.The protocol allows the conversion of various ketoximes into amide,thioamide,tetrazole and imide products in modular procedures.The generality and tolerance of functionalities of this method have been demonstrated.

关 键 词：Beckmann rearrangement Multiple components reaction AMIDE THIOAMIDE TETRAZOLE 

分 类 号：O621.25[理学—有机化学]