涎腺粘液表皮样癌与腺样囊性癌基因突变及靶向治疗研究  

Study on Gene Mutation and Targeted Therapy of Mucoepidermoid Carcinoma and Adenoid Cystic Carcinoma of Salivary Gland

作　　者：吴玉斌 李先明[1] WU Yu-bin;LI Xian-ming(Department of Radiation Oncology,the Second Clinical Medical College of Jinan University/Shenzhen People's Hospital,Shenzhen 518000,Guangdong,China)

机构地区：[1]暨南大学第二临床医学院/深圳市人民医院放射肿瘤科,广东深圳518000

出　　处：《医学信息》2022年第11期64-67,共4页Journal of Medical Information

摘　　要：涎腺肿瘤是一种罕见且具有异质性的恶性肿瘤,占所有恶性肿瘤中的比例小于1%,发病率较低。该病的病理类型复杂,世界卫生组织(WHO)将其分为22种病理类型,其中涎腺粘液表皮样癌与腺样囊性癌是其发病率最高的病理类型。初发病例常以外科切除和放射治疗为主,复发或远处转移以系统治疗为主。因肿瘤的罕见性和异质性,经典化疗药物难以开展大规模的临床研究,且经典化疗药物的疗效有限。涎腺肿瘤的基因突变是其特征,随着靶向治疗在不同组织学类型中存在的靶点证据越来越多,针对基因改变的靶向治疗丰富了涎腺肿瘤的治疗选择。本文就涎腺恶性肿瘤涎腺粘液表皮样癌与腺样囊性癌亚型中存在已知的基因突变和异常蛋白表达以及相关的靶向治疗现状作一综述,以期为临床治疗提供参考。Salivary gland tumor is a rare and heterogeneous malignant tumor,accounting for less than 1%of all malignant tumors.The pathological type of the salivary gland tumor is complex,and it is divided into 22 pathological types by the World Health Organization(WHO),among which mucoepidermoid carcinoma and adenoid cystic carcinoma of the salivary gland are the pathological types with the highest incidence.Surgical resection and radiotherapy are the main treatment for primary cases,and systemic treatment is the main treatment for recurrence or distant metastasis.Because of the rareness and heterogeneity of tumors,classical chemotherapy drugs are difficult to carry out large-scale clinical studies,and the efficacy of classical chemotherapy drugs is limited.The gene mutation of salivary gland tumors is its characteristic.With the increasing evidence of target in different histological types of targeted therapy,targeted therapy for gene change enriches the treatment options of salivary gland tumors.In this paper,we reviewed the known gene mutation,abnormal protein expression and related targeted therapy in salivary gland mucoepidermoid carcinoma and adenoid cystic carcinoma subtypes of salivary gland malignant tumor,in order to provide reference for clinical treatment.

关 键 词：粘液表皮样癌 腺样囊性癌 基因突变 靶向治疗 

分 类 号：R739.87[医药卫生—肿瘤]