基因突变特征与儿童及青少年分化型甲状腺癌远处转移相关性的meta分析  

Meta-analysis of the association between gene alterations and distant metastasis of differentiated thyroid carcinoma in children and adolescents

作　　者：邓姝婷 冯源 钱凯 郭凯 王卓颖 DENG Shuting;FENG Yuan;QIAN Kai;GUO Kai;WANG Zhuoying(Department of Head and Neck Surgery,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200001,China)

机构地区：[1]上海交通大学医学院附属仁济医院头颈外科,上海200001

出　　处：《中国癌症杂志》2022年第5期388-396,共9页China Oncology

基　　金：国家自然科学基金(81972496,81772852);上海市自然科学基金(16ZR1406600);2020年度黄浦区领军人才计划;共青团上海交通大学医学院委员会“甲状腺肿瘤防治”青年科技创新工作室。

摘　　要：背景与目的:甲状腺癌是世界范围内增长率较高的恶性肿瘤之一,在儿童及青少年中甲状腺癌的发病率也在逐年增加。本研究旨在对基因突变特征与儿童及青少年分化型甲状腺癌(differentiated thyroid carcinoma,DTC)远处转移的相关性进行meta分析。方法:数据库搜索探究基因突变特征与儿童及青少年DTC远处转移相关性的研究,运用STATA 14.0软件分析与远处转移相关的基因突变特征。结果:纳入20项研究,共涉及1273例患者,分析结果显示,BRAF V600E突变阴性、RET基因融合阳性是儿童及青少年DTC远处转移的危险因素,而NTRK基因融合与远处转移未见明显相关性。结论:本研究发现了与儿童及青少年DTC远处转移相关的几个基因突变特征,有利于患者预后的评估及治疗方案的制定。Background and purpose:Thyroid cancer is one of the fastest increasing malignancies worldwide,and its incidence in children and adolescents has also been increasing over the years.Meta-analysis were performed to investigate the correlation between gene alteration patterns and distant metastasis of differentiated thyroid carcinoma(DTC)in children and adolescents.Methods:Databases were used to search studies on the association between gene alteration patterns and distant metastasis of DTC in children and adolescents,and STATA 14.0 software was used to analyze the gene alterations related to distant metastasis.Results:Twenty studies involving 1273 patients were included,and the analysis showed that negative BRAF V600E mutation and positive RET gene fusion were risk factors for distant metastasis in DTC in children and adolescents,while NTRK gene fusion was not significantly associated with distant metastasis.Conclusion:Our research identified several genetic alterations associated with distant metastasis in DTC in children and adolescents,which could be guidance for prognosis assessment and treatment planning.

关 键 词：分化型甲状腺癌 儿童及青少年 远处转移 基因突变 

分 类 号：R736.1[医药卫生—肿瘤]