慢性阻塞性肺疾病与脑小血管病的孟德尔随机化研究  

Mendelian randomization study of chronic obstructive pulmonary disease and cerebral small vessel disease

作　　者：蔚文锴 史长河[1] 史晶晶 李玉生[1] YU Wenkai;SHI Changhe;SHI Jingjing;LI Yusheng(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院,河南郑州450052

出　　处：《中国实用神经疾病杂志》2022年第3期316-319,共4页Chinese Journal of Practical Nervous Diseases

基　　金：国家自然科学基金面上项目(编号:82171300)。

摘　　要：目的旨在验证慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)与脑小血管病(cerebral small vessel disease,CSVD)中脑白质损伤之间是否存在真正的因果关系。方法采用双样本孟德尔随机化研究,使用COPD中的遗传变异作为工具变量,并使用白质完整性(white matter integrity,WMI)中平均弥散率(mean diffusivity,MD)和各向异性分数(fractional anisotropy,FA)的全基因组关联研究数据作为CSVD中脑白质损伤的结局事件。结果孟德尔随机化的逆方差加权分析显示COPD与WMI-MD(P=0.458,OR=1.150,95%CI=0.795~1.662)及WMIFA(P=0.055,OR=0.759,95%CI=0.572~1.006)之间差异均无统计学意义。结论未发现COPD与CSVD中脑白质损伤之间存在因果关系。Objective This study set out to determine whether there is a true causal association between COPD and white matter damage of CSVD.Methods A two-sample Mendelian randomization design was em ployed,using genetic variants underlying COPD as instrumental variables and the white matter integrity(mean dif fusivity(MD)&fractional anisotropy(FA))genome-wide association study data for white matter damage of CSVD outcomes.Results Inverse variance weighted analysis of Mendelian randomization showed no statistically signifi cant difference between COPD and neither WMI-MD(P=0.458,OR=1.150,95%CI=0.795-1.662)nor WMIFA(P=0.055,OR=0.759,95%CI=0.572-1.006).Conclusion This study found no causal association between COPD and white matter damage of CSVD.

关 键 词：脑小血管病 脑白质完整性 慢性阻塞性肺病 德尔随机化研究 

分 类 号：R743[医药卫生—神经病学与精神病学]