Altered thalamic subregion functional networks in patients with treatment-resistant schizophrenia  

作　　者：Woo-Sung Kim Jie Shen Uyanga Tsogt Soyolsaikhan Odkhuu Young-Chul Chung 

机构地区：[1]Department of Psychiatry,Jeonbuk National University,Jeon-ju 54907,South Korea

出　　处：《World Journal of Psychiatry》2022年第5期693-707,共15页世界精神病学杂志

基　　金：Supported by the Korean Mental Health Technology R&D Project,Ministry of Health&Welfare,Republic of Korea,No.HL19C0015;the Korea Health Technology R&D Project through the Korea Health Industry Development Institute;funded by the Ministry of Health&Welfare,Republic of Korea,No.HR18C0016.

摘　　要：BACKGROUND The thalamus plays a key role in filtering information and has extensive interconnectivity with other brain regions.A large body of evidence points to impaired functional connectivity(FC)of the thalamocortical pathway in schizophrenia.However,the functional network of the thalamic subregions has not been investigated in patients with treatment-resistant schizophrenia(TRS).AIM To identify the neural mechanisms underlying TRS,we investigated FC of thalamic sub-regions with cortical networks and voxels,and the associations of this FC with clinical symptoms.We hypothesized that the FC of thalamic subregions with cortical networks and voxels would differ between TRS patients and HCs.METHODS In total,50 patients with TRS and 61 healthy controls(HCs)matched for age,sex,and education underwent resting-state functional magnetic resonance imaging(rs-fMRI)and clinical evaluation.Based on the rs-fMRI data,we conducted a FC analysis between thalamic subregions and cortical functional networks and voxels,and within thalamic subregions and cortical functional networks,in the patients with TRS.A functional parcellation atlas was used to segment the thalamus into nine subregions.Correlations between altered FC and TRS symptoms were explored.RESULTS We found differences in FC within thalamic subregions and cortical functional networks between patients with TRS and HCs.In addition,increased FC was observed between thalamic subregions and the sensorimotor cortex,frontal medial cortex,and lingual gyrus.These abnormalities were associated with the pathophysiology of TRS.CONCLUSION Our findings suggest that disrupted FC within thalamic subregions and cortical functional networks,and within the thalamocortical pathway,has potential as a marker for TRS.Our findings also improve our understanding of the relationship between the thalamocortical pathway and TRS symptoms.

关 键 词：Treatment-resistant schizophrenia THALAMUS Rs-fMRI Functional connectivity Thalamocortical pathway 

分 类 号：R749.3[医药卫生—神经病学与精神病学]