模拟移动床色谱在多组分糖液分离中的研究应用进展  

Development and research of simulated moving bed chromatography in separation of multi-fraction saccharides

作　　者：李云飞 栾庆民[1,2] 刘峰[1] 孙桂莲 张莉[1] 李珍珍 李克文[1,2] LI Yunfei;LUAN Qingmin;LIU Feng;SUN Guilian;ZHANG Li;LI Zhenzhen;LI Kewen(Baolingbao Biotechnology Co.Ltd.,Yucheng 251200,China;Shandong Provincial Key Laboratory of Extraction and Application Technology for Functional Glycomics,Yucheng 251200,China;School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai 200240,China)

机构地区：[1]保龄宝生物股份有限公司,山东禹城251200 [2]山东省功能糖提取与应用技术重点实验室,山东禹城251200 [3]上海交通大学农业与生物学院,上海200240

出　　处：《食品与发酵工业》2022年第11期338-344,共7页Food and Fermentation Industries

基　　金：2019年泰山产业领军人才项目(传统产业创新类);2020年度山东省重点研发计划(2020CXGC010601)。

摘　　要：近些年,关于模拟移动床(simulated moving bed,SMB)色谱在多组分糖液分离方面的应用有大量的相关报道,但是在系统配置与运行模式方面却鲜有归纳总结。该文基于国内外期刊论文和专利文献,分析了SMB色谱的结构变化特点和运行策略。与常规SMB色谱比较,近几年SMB色谱柱配置数量趋于少量化、各区数量多样化。进出口切换时间和顺序逐步细化,通过模拟预测各组分的前锋位移信息,实现多组分的精准分离。发挥批处理色谱和SMB色谱各自优势,两种色谱结合运行模式越来越多。A large number of papers and patents on simulated moving bed(SMB)chromatography used in the separation of multi-fraction saccharides have been published recently.However,the comprehensive review on the column configuration and operation strategies of SMB was limited.Compared with classic SMB,the following characteristics and operating strategies were summarized:the number of columns tends to be fewer and variable;switch time of ports is divided more substeps;the profile front of concentration is predicted and separated more accurately;the combination of batchwise chromatography and SMB has been employed widely to make full use of each advantage.

关 键 词：模拟移动床 色谱 多组分 结构 运行模式 

分 类 号：O652.63[理学—分析化学] O636.1[理学—化学]