Future therapies for pancreatic carcinoma:Insights into cancer precision medicine  

作　　者：Qiu-Yu Jiang Zhi-Xue Chen Si Zhang Ru-Yi Xue 

机构地区：[1]Department of Gastroenterology and Hepatology,Zhongshan Hospital,Shanghai Institute of Liver Disease,Fudan University,Shanghai 200032,China [2]NHC Key Laboratory of Glycoconjugate Research,Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Shanghai Medical College,Fudan University,Shanghai 200032,China

出　　处：《World Journal of Gastroenterology》2022年第22期2523-2526,共4页世界胃肠病学杂志（英文版）

摘　　要：Pancreatic carcinoma(PC)has one of the highest rates of cancer-related death worldwide.Except for surgery,adjuvant chemotherapy,chemoradiotherapy,and immunotherapy have shown various efficacies depending on the stage of the patient.We read the review“Current and emerging therapeutic strategies in pancreatic cancer:Challenges and opportunities”and offer some opinions that may improve its precision and completeness.This review presents a map of appropriate therapies for PC at different stages.Based on the clinical trial outcomes mentioned in the review,we evaluated the potential therapeutic options for PC and helped explain the contradictory efficacy between different programmed cell death protein 1/programmed cell death ligand 1 clinical trials,which may have resulted from the unique features of PC.Although R0 resection and adjuvant chemotherapy are still the gold standards for PC,new modalities,with or without clinical validation,are needed to establish more specific and precise treatments for PC.

关 键 词：Pancreatic carcinoma IMMUNOTHERAPY CHEMOTHERAPY RADIOCHEMOTHERAPY Future therapies 

分 类 号：R735.9[医药卫生—肿瘤]