高龄孕妇的染色体微阵列分析应用  

Application of Chromosome Microarray Analysis in Pregnant Women of Advanced Maternal Age

作　　者：郭君荣 刘丽[1] Guo Junrong;Liu Li(Department of Obstetrics and Gynecology,The Second Affiliated Hospital of Chongqing Medical University,Chong Qing 400010)

机构地区：[1]重庆医科大学附属第二医院妇产科,重庆400010

出　　处：《科学咨询》2022年第9期68-71,共4页

摘　　要：目的本研究旨在评估染色体微阵列分析在检测高龄孕妇(有无合并其他高危因素)胎儿染色体异常方面的价值。方法收集498例接受染色体微阵列分析的单胎高龄孕妇,根据孕期是否合并其他高危因素,将患者分为单纯高龄组和非单纯高龄组。采集患者的一般资料与染色体结果进行分析。结果非单纯高龄孕妇的总体胎儿染色体异常率与染色体数目异常率均明显高于单纯高龄组,非单纯高龄孕妇组中进一步发现合并NIPT异常、超声结构异常、不良接触史及不良孕育史的孕妇胎儿染色体异常率较高。结论针对合并其他高危因素的高龄孕妇,医生应强烈建议其行侵入性产前诊断,明确胎儿染色体状态。Objective The purpose of this study was to evaluate the value of chromosomal microarray analysis in detecting chromosomal abnormalities in fetuses of women of advanced maternal age(with or without other risk factors).Methods A total of 498 single fetal pregnant women who underwent chromosome microarray analysis were divided into simple aged group and non-simple aged group according to whether there were other risk factors during pregnancy.General data and chromosomal results of patients were collected for analysis.Results The total chromosomal abnormality rate and chromosomal number abnormality rate of nonsimple aged pregnant women were significantly higher than that of the simple aged pregnant women,and the chromosomal abnormality rate of non-simple aged pregnant women with NIPT abnormality,ultrasound abnormality,adverse contact history and adverse gestation history was higher.Conclusion For aged pregnant women with other high risk factors,doctors should recommend they to receive invasive prenatal diagnosis to diagnose the fetal chromosome abnormalities.

关 键 词：染色体微阵列分析 高龄孕妇 拷贝数变异 产前诊断 

分 类 号：R71[医药卫生—妇产科学]