Chicory polysaccharides alleviate high-fat diet-induced non-alcoholic fatty liver disease via alteration of lipid metabolism-and inflammation-related gene expression  

作　　者：Shengjie Li Yulong Wu Haitao Jiang Feng Zhou Ailing Ben Renlei Wang Chun Hua 

机构地区：[1]School of Food Science,Nanjing Xiaozhuang University,Nanjing 211171,China [2]Jiangsu Provincial Key Construction Laboratory of Special Biomass Byproduct Resource Utilization,Nanjing 211171,China [3]Nanjing Key Laboratory of Quality and safety of agricultural products,Nanjing 211171,China [4]Biology Department,Jiangsu Second Normal University,Nanjing 210013,China

出　　处：《Food Science and Human Wellness》2022年第4期954-964,共11页食品科学与人类健康（英文）

基　　金：supported by the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (18KJD180002;20KJA416003;20KJA416003;18KJA180007);the Key Subject of Ecology of Jiangsu Province (SUJIAOYANHAN[2022]No.2);Excellent Scientific and Technological Innovation Team of Colleges and Universities of Jiangsu Province (SUJIAOKE[2021]No.1);the Key Subject of Biology of Nanjing (NINGJIAOGAOSHI[2021] No.16);the Youth program of Nanjing Xiaozhuang University (2019NXY47)。

摘　　要：Administration of chicory polysaccharides(CP) can modify lipid metabolism, improve dyslipidemia, and reduce liver inflammation, all of which may help alleviate non-alcoholic fatty liver disease(NAFLD). However, the underlying mechanisms remain unclear. This study aimed to gain further understanding of the potential molecular mechanisms that mediate the protective effects of CP against NAFLD via transcriptomic and metabolomic analyses. Hepatic RNA-sequencing analysis demonstrated that long-term intake of CP restored expression of lipid metabolism-related genes Xbp1, Insig2, and Cth in NAFLD rats, thereby inhibiting de novo lipogenesis. Moreover, CP consumption restored expression levels of genes involved in pro-inflammatory responses, such as Irf1. In addition, metabolic data confirmed that CP treatment increased levels of L-palmitoylcarnitine and hexadecanoyl-Co A, implying that CP administration can promote hepatic fatty acid β-oxidation. The present results demonstrate the underlying mechanisms of CP in high-fat dietinduced NAFLD rats and suggest that CP treatment might provide a dietary therapeutic tool for the treatment of NAFLD in humans.

关 键 词：Chicory polysaccharides Non-alcoholic fatty liver disease TRANSCRIPTOME METABOLOME 

分 类 号：TS201.4[轻工技术与工程—食品科学]