Roles of Adinandra nitida(Theaceae) and camellianin A in HCl/ethanol-induced acute gastric ulcer in mice  

作　　者：Erdong Yuan Yingyi Lian Qiuhua Li Zhaoxiang Lai Lingli Sun Xingfei Lai Ruohong Chen Shuai Wen Junquan Zhu Wenji Zhang Shili Sun 

机构地区：[1]School of Food Science and Engineering,South China University of Technology,Guangzhou 510641,China [2]Tea Research Institute,Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of Tea Resources Innovation&Utilization,Guangzhou 510640,China [3]Guangdong Society of Plant Protection,Guangdong 510640,China

出　　处：《Food Science and Human Wellness》2022年第4期1053-1063,共11页食品科学与人类健康（英文）

基　　金：funded by the “14th Five-Year Plan” team-building projects of Guangdong Academy Agricultural Sciences (202126TD);National Natural Science Foundation of China (81903319, 81803236, 31800295);Guangdong Science and Technology program (2018KJYZ002);Guangdong Basic and Applied Basic Research Foundation (2020A1515011266);Qingyuan Science and Technology Program (DZXQY021, 181022114566189, 181022114566189, 2019A039, 2020KJJH042);Shaoguan Science and Technology Program (2018CS11902, 2018sn081);Guangzhou Science and Technology Program (202002030202);Zhaoqing Science and Technology Program (2019N001, 2019N013);Maoming Science and Technology Program (mmkj2020045);Zhanjiang Science and Technology Program (2020A03014);Yingde Science and Technology Board (JHXM2018029);Innovation Fund projects of Guangdong Academy of Agricultural Sciences (202115);Special fund for scientific innovation strategy-construction of high level Academy of Agriculture Science (R2019PY-JX004, R2018YJ-YB3002, R2016YJYB3003, R2018PY-QF005, R2018QD-101)。

摘　　要：Gastric ulcer is a global health concern nowadays. Adinandra nitida, known as Shibi tea, is a flavonoidrich plant found in South China. A. nitida possesses many healthy properties, such as antioxidation and reducing blood pressure. However, its effects on gastric ulcer have not been investigated. This study aimed to investigate the effects of the Shibi tea water extract(STE) and its main flavonoid camellianin A(CA) in hydrochloric acid(HCl) and ethanol(Et OH)-induced acute gastric ulcer in mice. Administration of CA and STE for continuous two days after stimulation by HCl/Et OH significantly attenuated the deterioration of gastric mucosal damage by lowering the gross gastric mucosal index, histopathological injury index, the oxidative stress, the expression of the inflammatory cytokines TNF-α and IL-6, and the expression of inflammatory mediators i NOS and COX-2. Western blotting and immunohistochemistry analysis showed that CA and STE regulated the inflammatory signaling pathway protein levels of IκB-α and NF-κB. Taken together, our study verified that CA and STE have antioxidative and anti-inflammatory effects in gastric ulcer mice. We propose that A. nitida should be developed as natural functional food for acute gastric ulcer patients base on the gastroprotective effects of STE and its main flavonoid CA.

关 键 词：Adinandra nitida(Theaceae) Camellianin A Gastric ulcer Oxidative stress ANTI-INFLAMMATION 

分 类 号：TS201.4[轻工技术与工程—食品科学]