Multifaceted neuroprotective effects of(-)-epigallocatechin-3-gallate(EGCG)in Alzheimer's disease:an overview of pre-clinical studies focused onβ-amyloid peptide  

作　　者：Kumju Youn Chi-Tang Ho Mira Jun 

机构地区：[1]Department of Food Science and Nutrition,Dong-A University,Busan 49315,Korea [2]Department of Food Science,Rutgers University,NJ 08901,USA [3]Department of Health Sciences,The graduate School of Dong-A University,Busan 49315,Korea

出　　处：《Food Science and Human Wellness》2022年第3期483-493,共11页食品科学与人类健康（英文）

基　　金：supported by Dong-A University。

摘　　要：Alzheimer’s disease(AD)is the most common neurodegenerative disease characterized by cognitive decline and memory impairment.Many lines of evidence indicate that excessiveβ-amyloid peptide(Aβ)generation and aggregation play pivotal roles in the initiation of AD,leading to various biochemical alteration including oxidative damage,mitochondrial dysfunction,neuroinflammation,signaling pathway and finally resulting in neuronal death.AD has a complex pathogenic mechanism,and a single-target approach for anti-AD strategy is thus full of challenges.To overcome these limitations,the present study focused to review on one of multiple target-compounds,(-)-epigallocatechin-3-gallate(EGCG)for the prevention and treatment of AD.EGCG is a main bioactive polyphenol in green tea and has been reported to exert potent neuroprotective properties in a wide array of both cellular and animal models in AD.This review demonstrated multiple neuroprotective efficacies of EGCG by focusing on the involvement of Aβ-evoked damage and its Aβregulation.Furthermore,to understand its mechanism of action on the brain,the permeability of the blood-brain barrier was also discussed.

关 键 词：Alzheimer’s disease β-Amyloid peptide Green tea EGCG NEUROINFLAMMATION 

分 类 号：R749.16[医药卫生—神经病学与精神病学] TS272[医药卫生—临床医学]