Capsular polysaccarides of probiotics and their immunomodulatory roles  

作　　者：Jing Li Saisai Feng Leilei Yu Jianxin Zhao Fengwei Tian Wei Chen Qixiao Zhai 

机构地区：[1]State Key Laboratory of Food Science and Technology,Jiangnan University,Wuxi 214122,China [2]School of Food Science and Technology,Jiangnan University,Wuxi 214122,China [3]National Engineering Research Center for Functional Food,Jiangnan University,Wuxi 214122,China

出　　处：《Food Science and Human Wellness》2022年第5期1111-1120,共10页食品科学与人类健康（英文）

基　　金：supported by the National Natural Science Foundation of China Program[31871773 and 31820103010];the Key Scientific and Technological Research Projects in the Key Areas of the Xinjiang Production and Construction Corps[2018AB010];National First-Class Discipline Program of Food Science and Technology[JUFSTR20180102];the BBSRC Newton Fund Joint Centre Award;Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province。

摘　　要：Studies have determined the immunomodulatory activities of cell-surface polysaccharides of lactic acid bacteria(LAB)and Bacteroides;however,the mechanisms,synthesis,regulation,structure,and functional links have not been systematically discussed.We first introduce the structure of the capsular poly saccharides(CPS s)of commonly studied probiotics and Bacteroides.Wzx-Wzy dependent and ATP-binding cassette(ABC)transporter-dependent pathways are the two main biosynthesis and secretion of CPS pathways.The genes known to be associated with these two pathways are mainly those associated with priming glycosyltransferase(pGT);a variable number of genes encoding for different glycosyl transferases(GTs);Wzx/Wzy-encoding enzymes related to flippases and polymerases;and ABC-transporter genes.In addition,the effects of CPSs on host immunity as well as their related underlying mechanisms are described.Surface polysaccharides on probiotics can serve as a mask to aid in their escape from attacks from the host’s immune system.In turn,they also exhibit immunomodulatory activities,such as strengthening the functions of macrophages,promoting the maturation of antigen-presenting cells,and inducing regulatory T cells.All of these effects of cell-surface polysaccharides exhibit their significant protective properties in immunocompromised diseases,such as colitis,arthritis,and dermatitis.Finally,we focused on their structure and functional links.

关 键 词：Capsular polysaccharides PROBIOTICS BACTEROIDES IMMUNOMODULATION 

分 类 号：TS201.3[轻工技术与工程—食品科学]