Cow milkα_(s1)-casein induces allergic responses in a mouse model of atopy  

作　　者：Guangyu Wang Xiaofeng Yu Yanjun Cong Linfeng Li 

机构地区：[1]Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients,College of Food and Health,Beijing Technology and Business University,Beijing 100048,China [2]Department of Dermatology,Beijing Friendship Hospital,Beijing 100050,China

出　　处：《Food Science and Human Wellness》2022年第5期1282-1289,共8页食品科学与人类健康（英文）

基　　金：supported by National Science and Technology Project in Rural Areas(China,2018YFC1604205);the National Natural Science Foundation of China(Beijing,China;31872886)。

摘　　要：α_(s1)-Casein is a potential allergen to induce hypersensitivity in cow milk.We had identifiedα_(s1)-casein and its epitopes in previous studies.The present study aimed to evaluate the allergic mechanism ofα_(s1)-casein in a BALB/c mouse model.The levels of specific IgE,mast cell proteinase,histamine and cytokines in sensitized mice were determined,and the clinical and pathological observation were evaluated.Results showed that the levels of specific IgE,mast cell proteinase,histamine,IL-4,IL-5,IL-10 increased significantly with a dose-dependent trend.The local alveolar septum collapsed or thickened,and lymphatic foci were produced in the spleen and thymus,and the inflammatory cells infiltrated in small intestinal mucosa mesenchyme.In conclusion,the levels of specific IgE,mast cell proteinase,histamine,IL-4,IL-5,IL-10 and some inflammatory factors could possibly serve as allergic biomarkers ofα_(s1)-casein,however,additional studies on signal transduction and gene expression are necessary in future.

关 键 词：Cow milk α_(s1)-Casein ALLERGEN BALB/c mouse model Allergic mechanism 

分 类 号：TS201.4[轻工技术与工程—食品科学]