Perspectives on diacylglycerol-induced improvement of insulin sensitivity in type 2 diabetes  

作　　者：Daoming Li Yang Zhu Yonghua Wang Qiong Zou Jinzhu Duan Dongxiao Sun-Waterhouse Baoguo Sun 

机构地区：[1]Beijing Advanced Innovation Center for Food Nutrition and Human Health,Beijing Technology and Business University,Beijing 100048,China [2]School of Food and Biological Engineering,Shaanxi University of Science and Technology,Xi’an 710021,China [3]School of Food Science and Engineering,Guangdong Research Center of Lipid Science and Applied Engineering Technology,South China University of Technology,Guangzhou 510640,China [4]Bioprocess Engineering,Wageningen University and Research,6700 AA Wageningen,Netherlands [5]Guangzhou Yong-h Special Nutrition Technology Co.Ltd,Guangzhou 510000,China [6]Guangzhou Institute of Pediatrics,Guangzhou Women and Children's Medical Center,Guangzhou 510623,China

出　　处：《Food Science and Human Wellness》2022年第2期230-237,共8页食品科学与人类健康（英文）

基　　金：supported by Chinese National Natural Foundation for Distinguished Young Scholars(31725022);Beijing Advanced Innovation Center for Food Nutrition and Human Health;Beijing Technology and Business University(BTBU)(20171049);the Science&Technology Department of Shaanxi Province(2019JM-333)。

摘　　要：Diacylglycerol(DAG)-based edible oils have attracted increasing research interest owing to their healthpromoting properties.Recent animal and human studies showed that an increased 1,2-DAG content in the liver and skeletal muscle may cause insulin resistance.However,earlier studies using animal models or humans reported that dietary DAGs with a 1,2-DAGs to 1,3-D AGs ratio of approximately 3:7 could improve insulin sensitivity in type 2 diabetic patients.This conflict raises the question of whether there is a link between the ingested DAGs and endogenous DAGs during their metabolism.To make a contribution to this field,this review provides an overview of the metabolic pathways of ingested DAGs and biological roles of DAGs(ingested and endogenous)in the change of insulin sensitivity.Accordingly,strategies for further investigations on the metabolism of DAGs are proposed.

关 键 词：DIACYLGLYCEROLS Functional oil Insulin sensitivity LIPIDOMICS 

分 类 号：TS201.2[轻工技术与工程—食品科学]