ALDH1、SOX2表达与卵巢浆液性肿瘤预后相关性  

Correlation between the expression of acetaldehyde dehydrogenase 1 and sex determining region Y-box protein 2 of patients with ovarian serous tumors and their prognosis

作　　者：崔艳超 李勤 崔艳平 王夏 姜虹 CUI Yanchao;LI Qin;CUI Yanping;WANG Xia;JIANG Hong(Shaanxi University of Traditional Chinese Medicine,Xianyang,Shaanxi Province,712046;The Second Affliiated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang;Northwest Womer's and Children's Hospital)

机构地区：[1]陕西中医药大学,咸阳712046 [2]陕西中医药大学第二附属医院 [3]西北妇女儿童医院

出　　处：《中国计划生育学杂志》2022年第6期1294-1299,共6页Chinese Journal of Family Planning

摘　　要：目的:探讨乙醛脱氢酶1(ALDH1)、性别决定区Y框蛋白2(SOX2)在卵巢浆液性肿瘤组织中的表达及与患者预后关系。方法:选取2017年6月--2018年6月在本院手术治疗的卵巢浆液性肿瘤患者79例,收集患者一般资料及临床病理参数,术中收集患者病理组织标本,根据病理结果分为卵巢浆液性癌组(恶性组,54例),卵巢交界性浆液性肿瘤组(交界性组,15例),卵巢浆液性囊腺瘤组(良性组,10例),免疫组织化学染色法检测组织中ALDH1、SOX2蛋白表达情况,随访患者3年,分析ALDH1、SOX2表达水平与患者临床病理参数关系及影响患者预后的因素;Pearson法分析组织中ALDH1与SOX2表达相关性;Kaplan-Meier法分析不同ALDH1、SOX2表达水平与患者生存时间关系。结果:ALDH1、SOX2蛋白在卵巢浆液性癌组织中均呈高表达,ALDH1蛋白在恶性组、交界性组、良性组病理组织中高表达率(66.7%、46.8%、20.0%),SOX2蛋白高表达率(83.3%、26.7%、20.0%)均逐渐降低(P<0.05);病理组织中ALDH1与SOX2表达呈正相关(P<0.05)。经单因素分析显示,FIGO分期、淋巴结有无转移、盆腔侵犯、大网膜转移、Ki-67、ALDH1、SOX2蛋白表达均与患者预后有关(P<0.05);Kaplan-Meier分析显示,ALDH1蛋白、SOX2蛋白高表达组患者3年累积生存率均低于低表达组(P=0.000)。结论:ALDH1、SOX2在卵巢浆液性癌组织中均呈高表达且表达正相关,表达水平与患者病情发展密切相关,对预测患者预后有一定参考价值。Objective:To investigate the expression of acetaldehyde dehydrogenase 1(ALDH1)and sex determining region Y-box protein 2(SOX2)in the ovarian serous tumor tissues of the patients,and to study the correlation between the ALDH1 and SOX2 levels of the patients and their prognosis.Methods:From June 2017 to June 2018,79 patients with ovarian serous tumors who would surgically treat were selected as the research objects,and the general information and clinicopathological parameters of the patients were collected.79 pathological tissue specimens of these patients were collected during the operation,and these patients were divided into group A(54 cases with malignant ovarian serous tumors),group B(15 cases with ovarian borderline serous tumor),and group C(10 cases with benign ovarian serous cystadenoma)according to their pathological results.The expressions of ALDH1 and SOX2 proteins in the tissues were detected by immunohistochemical staining.These patients were followed up for 3 years.The correlation between ALDH1 and SOX2 expression levels of the patients and their clinical pathological parameters and the factors affecting the prognosis of the patients were analyzed.Pearson method was used to analyze the correlation between the expression level of ALDH1 in ovarian serous tumor tissue of the patients and their SOX2 level.Kaplan-Meier method was used to analyze the correlation between the different ALDH1 and SOX2 expression levels of the patients and their survival time.Results:The high expression rates of ALDH1 protein in serous ovarian serous tumors tissues of the patients in group A,group B,and group C were 66.7%,46.8%,and 20.0%,respectively,and the high expression rates of SOX2 protein in serous ovarian serous tumors tissues of the patients in group A,group B,and group C were83.3%,26.7%,and 20.0%,respectively,which were all decreased gradually(P<0.05).There was a positive correlation between the ALDH1 expression and the SOX2 expression in pathological tissues(P<0.05).Univariate analysis showed that the FIGO stage,the

关 键 词：卵巢浆液性肿瘤 乙醛脱氢酶 性别决定区Y框蛋白2 组织中表达 生存预后 

分 类 号：R737.31[医药卫生—肿瘤]