生物信息学在医学微生物领域研究生教学中的应用与思考  

Application and thinking of bioinformatics teaching in graduate students who had a medical microbiology back⁃ground

作　　者：蒋琰[1] 伍雪晴 俞云松[1] JIANG Yan;WU Xueqing;YU Yunsong(Department of Infectious Diseases,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310016,China)

机构地区：[1]浙江大学医学院附属邵逸夫医院感染科,浙江杭州310016

出　　处：《全科医学临床与教育》2022年第6期534-537,共4页Clinical Education of General Practice

基　　金：浙江省自然科学基金项目(LY22H190001)。

摘　　要：目的探讨生物信息学在医学微生物领域研究生教学中的应用与思考。方法总结十余年的教学经验,通过整理医学微生物领域实例,建立生物信息学分阶段教学的方法。结果生物信息学主要运用计算机科学、数学的思路和方法并结合生物学工具来阐明和理解大量数据中包括的生物学意义。医学微生物领域近些年在科研上发展很快,十分依赖生物信息学对其大数据的解析和处理工作。在医学微生物背景的研究生教学过程中,生物信息学的学习可以分为三个阶段,一是对概念看得懂、应用懂得用的基本概念阶段;二是会搭建平台、会灵活运用的进阶阶段;三是会编程、懂算法的高级阶段。同时,需要鼓励学生在学习过程中注重实践和应用,并积极阅读原文文献,跟上最新的学科发展步伐。结论通过借助这些方法和经验,在实际教学过程中帮助学生走出生物信息学学习的误区,打好学习的基础,能够将学科用于真正的科研实践当中。Objective To explore the application and thinking of bioinformatics teaching in graduate students who had a medical microbiology background.Methods Based on teaching experience in last decade,multi-stage teaching pattern can be constructed through lots of instance on medical microbiology.Results In bioinformatics,many thoughts and methods based on computer science and mathematics combined with biological tools were employed to elucidate and understand the biology interpretation within big data.Research of medical microbiology developed rapidly in recent years and relied on the data analysis by bioinformatics tools.During the bioinformatics teaching in graduate students who had a medical microbiology background,the curriculum can be divided into three stages.Firstly,the fundamental concept stage requires students to understand the biology concept and how to use the web tools.Secondly,the promotion stage requests constructing the data analysis platform or applying the command-line tools.Lastly,the superior stage asks for understanding the computer programming and algorithm.Moreover,practice and application should be encouraged for students and reading original research papers can be a good method to acquire the new scientific information.Conclusion These methods and experiences around bioinformatics teaching can help graduate students get rid of the misunderstandings and lay a solid study foundation,utilizing the knowledge for real science and research.

关 键 词：生物信息学 教学 医学微生物 

分 类 号：G643[文化科学—高等教育学] R-4[文化科学—教育学]