孕酮受体在人子宫内膜基质细胞蜕膜化过程中的作用机制研究现状  

Current research status of mechanism of progesterone receptor in human endometrial stroma cell deciduation

作　　者：黄品秀 曾定元 Huang Pinxiu;Zeng Dingyuan(Reproductive Medicine Center,Liuzhou Maternity and Child Healthcare Hospital,Liuzhou 545001,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]广西壮族自治区柳州市妇幼保健院生殖医学中心,545001

出　　处：《中华妇幼临床医学杂志（电子版）》2022年第2期245-248,共4页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：国家自然科学基金项目(82001553、82160296);广西壮族自治区自然科学基金项目(2019JJB140179);广西壮族自治区重点研发计划(桂科AB18126056);柳州科技重点研发计划(2018BJ10301);柳州市科技计划项目(2018DB20501)。

摘　　要：人子宫内膜基质细胞蜕膜化(hESCD),是人类胚胎植入和维持妊娠的关键环节。hESCD主要是指排卵后,子宫内膜在孕酮与孕酮受体(PGR)作用下,发生一系列生物学、形态学改变及细胞外基质重建。但是,对于孕酮-PGR信号通路在hESCD过程中的具体分子作用机制,迄今尚未阐明。笔者拟就PGR结构及其亚型,hESCD过程中孕酮-PGR信号通路的生理作用、网络调控,以及PGR水平及其功能异常与hESCD异常疾病关系4个方面的最新研究进展进行阐述。Human endometrial stroma cell decidualization(hESCD)is a key link in embryo implantation and pregnancy maintenance.hESCD mainly means that endometrium undergoes a series of biological and morphological changes and extracellular matrix reconstruction by effects of progesterone and progesterone receptor(PGR)after ovulation.However,up to now,the specific molecular mechanism of progesterone-PGR signal pathway in hESCD has not been fully elucidated.This paper focuses on recent research status of the structure and subtypes of PGR,physiological function and regulation network of progesterone-PGR signal pathway,and relationship between abnormal PGR and abnormal diseases of hESCD.

关 键 词：受体 孕酮 孕酮抵抗 子宫内膜异位症 子宫内膜蜕膜化 反复种植失败 胚胎植入 女(雌)性 

分 类 号：R73[医药卫生—肿瘤]