Endophilin在内吞及相关疾病中的作用  

Roles of Endophilin in endocytosis and related diseases

作　　者：李晓萌 李晓伟 朱文华 孟列素 LI Xiaomeng;LI Xiaowei;ZHU Wenhua;MENG Liesu(School of Basic Medical Sciences,Xi′an Jiaotong University Health Science Center,Xi′an 710061,China;National-Local Joint Engineering Research Center of Biodiagnostics&Biotherapy,The Second Affiliated Hospital of Xi′an Jiaotong University,Xi′an 710061,China)

机构地区：[1]西安交通大学医学部基础医学院,西安710061 [2]西安交通大学第二附属医院,生物诊断治疗国家地方联合工程研究中心,西安710061

出　　处：《生命的化学》2022年第2期184-194,共11页Chemistry of Life

基　　金：国家自然科学基金项目(82171784,82171724,32070913);2019年度教育部“春晖计划”合作科研项目;陕西省自然科学基金项目(2020JQ082)。

摘　　要：内吞作用是细胞摄入大分子或颗粒性物质的过程,根据是否需要网格蛋白参与可分为网格蛋白介导的内吞作用和非网格蛋白介导的内吞作用。已有研究显示,胞质蛋白Endophilin在多种内吞途径中均发挥重要作用。本文主要介绍了Endophilin家族的基本特性及其在内吞机制中的生物学功能,回顾了该家族在多种类型疾病中的研究进展,并对Endophilin在内吞分子机制和疾病诊疗潜能研究方面进行了展望。Endocytosis is a process through which macromolecules or granular substances are transported into cells.It can be classified as clathrin-mediated endocytosis and clathrin-independent endocytosis based on whether clathrin is required.Previous studies have shown that Endophilin,a cytoplasmic protein,plays a vital role in a variety of endocytic pathways.This review mainly introduces the basic characteristics of the Endophilin family and its biological function in the endocytosis mechanism,discusses the research progress of the family in many kinds of diseases,and puts forward the prospect of Endophilin research on the endocytic molecular mechanism and disease diagnosis potential.

关 键 词：ENDOPHILIN 内吞作用 Endophilin介导的快速内吞作用 信号转导 疾病 

分 类 号：R363[医药卫生—病理学]