National Natural Science Foundation of China(82271241 and 82001172 to XLZ,81801112 to MXX);Guangdong Basic and Applied Basic Research Foundation(2022A1515012389 to MXX,2022A1515012543 to RCL);Young Talent Support Project of Guangzhou Association for Science and Technology(QT20220101169 to XLZ);Excellent Young Talents Project of Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences(KY012021188 to XLZ);Science and Technology Projects in Guangzhou(202201010792 to RCL)。
Background Tactile and mechanical pain are crucial to our interaction with the environment,yet the underpinning molecular mechanism is still elusive.Endophilin A2(EndoA2)is an evolutionarily conserved protein that is ...
supported byNational Natural Science Foundation of China(No.31970480);Natural Science Foundation of Henan province(No.212300410063);Young Elite Scientist Sponsorship Program by China Association for Science and Technol-0gy(YESS 20150026).
Oocyte maturation is critical for insect reproduction.Vitellogenesis,the timely production and uptake of vitellogenin(Vg),is crucial for female fecundity.Vg is synthesized in fat body and absorbed by the oocytes throu...
supported by funding from the National Key R&D program of China (2019YFA0801900 to JR Speakman, 2016YFA0500100 to J-J. Liu);the National Natural Science Foundation of China (92057206 to JR Speakman, 31530039 to J-J. Liu and 32070785 to Y. Yang);the Strategic Priority Research Program of Chinese Academy of Science (XDB32020100 to J-J. Liu and XDB13030100 to JR Speakman)
Food intake is generally assumed to reflect a regulatory tension between homeostatic and hedonic drivers.Information from individuals with memory dysfunction suggests that episodic memory may also play a significant r...
the National Natural Science Foundation of China(Key grant numbers 81230082,81302771,81525025,81473206,81573422,81773721,and 81500226);the Natural Science Foundation of Guangdong Province(2018A030310233);The Fundamental Research Funds for the Central Universities(number 18zxxt74).
TMEM16A Ca^2+-activated chloride channel(CaCC)plays an essential role in vascular homeostasis.In this study we investigated the molecular mechanisms underlying downregulation of TMEM16A CaCC activity during hypertensi...