脂肪酸及其代谢物与膀胱癌生物学行为关系研究进展  

Research progress on the relationship between fatty acids and their metabolites and biological behavior of bladder cancer

作　　者：徐文楷 黄应龙[1] 王侨 王剑松[1] 王海峰 XU Wenkai;HUANG Yinglong;WANG Qiao;WANG Jiansong;WANG Haifeng(Department of Urology,Kunming Medical University,Yunnan Clinical Medical Center for Urinary Diseases,Kunming 650101,China)

机构地区：[1]昆明医科大学第二附属医院泌尿外科,云南省泌尿系统疾病临床医学中心,云南昆明650101

出　　处：《现代泌尿外科杂志》2022年第6期521-525,共5页Journal of Modern Urology

基　　金：国家自然科学基金(No.81660422、81860452)。

摘　　要：增强的脂肪酸代谢不仅为肿瘤增殖提供了充足能量,也为肿瘤细胞膜及血管生成提供了丰富的生物原料。同样,脂肪酸合成与氧化在膀胱癌中异常活跃,并且与膀胱癌的恶性生物行为密切相关。本文对脂肪酸代谢与膀胱癌的发生、发展以及作用机制做一综述,为膀胱癌的早期诊断及治疗研究提供新思路。Enhanced fatty acid metabolism provides not only sufficient energy for tumor proliferation,but also abundant biological materials for tumor cell membrane and angiogenesis.Fatty acid synthesis and oxidation are highly active in bladder cancer and are closely related to the malignant biological behavior of bladder cancer.In this paper,we will review the relationship between fatty acid metabolism and the pathogenesis and mechanism of bladder cancer,hoping to provide a new idea for the early diagnosis and treatment of bladder cancer.

关 键 词：脂肪酸 膀胱 恶性肿瘤 肿瘤预后 代谢重编程 多不饱和脂肪酸 

分 类 号：R737[医药卫生—肿瘤]